Rebello-Sanchez Ingrid, Vasquez-Avila Karen, Parente Joao, Pacheco-Barrios Kevin, De Melo Paulo S, Teixeira Paulo E P, Jong Kian, Caumo Wolnei, Fregni Felipe
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.
Research Unit for the Generation and Synthesis of Evidence in Health, San Ignacio de Loyola University, Lima, Peru.
J Int Soc Phys Rehabil Med. 2022 Oct-Dec;5(4):129-148. doi: 10.4103/ijprm.jisprm-000167. Epub 2022 Dec 13.
Mind-body therapies (MBTs) use mental abilities to modify electrical neural activity across brain networks. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that modulates neuronal membrane potentials to enhance neuroplasticity. A combination of these treatment strategies may generate synergistic or additive effects, and thus has been more commonly tested in clinical trials, fostering a novel yet promising field of research. We conducted a literature search in four different databases including only randomized clinical trials (RCTs) that tested the combination of MBTs with tDCS. Ten studies (n=461) were included. Combined protocols included meditation/mindfulness (8/10), biofeedback (1/10), and hypnosis (1/10). The RCTs were heterogeneous with regards to population, design, and types of outcomes. Based on the findings of this search, we provide here a content description, methodological and practical insights, and future directions for the field. We hope this review will provide future authors with information to facilitate the development of trials with improved protocols.
身心疗法（MBTs）利用心理能力来改变大脑网络中的电神经活动。经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，可调节神经元膜电位以增强神经可塑性。这些治疗策略的组合可能会产生协同或累加效应，因此在临床试验中得到了更广泛的测试，从而催生了一个新颖且有前景的研究领域。我们在四个不同的数据库中进行了文献检索，仅纳入了测试MBTs与tDCS组合的随机临床试验（RCTs）。共纳入了10项研究（n = 461）。联合方案包括冥想/正念（8/10）、生物反馈（1/10）和催眠（1/10）。这些RCTs在人群、设计和结局类型方面存在异质性。基于此次检索的结果，我们在此提供该领域的内容描述、方法学和实践见解以及未来方向。我们希望这篇综述能为未来的作者提供信息，以促进采用改进方案的试验的开展。
