Department of Women's and Children's Health, University of Liverpool.
Department of Endocrinology, Alder Hey Children's NHS Foundation Trust.
J Hypertens. 2023 Feb 1;41(2):203-211. doi: 10.1097/HJH.0000000000003321. Epub 2022 Nov 2.
Acquired cardiovascular diseases account for much of the increased risk of premature death in patients with Turner syndrome (TS). Hypertension is a major modifiable cardiovascular risk factor. It has a high prevalence in TS developing at an early age and thus leading to prolonged exposure to high blood pressure. The aetiology for hypertension in TS is largely unknown. It is likely multifactorial, and recent hypotheses include altered sympathetic tone, vasculopathy and endocrine factors. In this review article we aim to provide a comprehensive review of data on mechanisms of hypertension in TS and their implication for diagnostics and optimal choice of antihypertensive treatments. Ultimately this knowledge should help prevent hypertension-related complications, and improve quality of life and life expectancy for patients with TS.
获得性心血管疾病是 Turner 综合征（TS）患者早逝风险增加的主要原因。高血压是一个主要的可改变的心血管危险因素。它在 TS 患者中发病率很高，并且会导致患者长期处于高血压状态。TS 患者高血压的病因尚不清楚。它可能是多因素的，最近的假说包括交感神经张力改变、血管病变和内分泌因素。在这篇综述文章中，我们旨在全面回顾 TS 患者高血压发病机制方面的数据，及其对诊断和最佳降压治疗选择的影响。最终，这些知识应该有助于预防与高血压相关的并发症，提高 TS 患者的生活质量和预期寿命。
