Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Sciences, Emory University School of Medicine, 1364 Clifton Road Northeast, 1st Floor #E163, Atlanta, GA 30322, USA.
Department of Medicine, Otago Medical School, University of Otago, 1st Floor, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand; Duke University Medical Center, Department of Radiology, 2301 Erwin Road, Box 3808, Durham, NC 27710, USA.
PET Clin. 2023 Apr;18(2):233-242. doi: 10.1016/j.cpet.2022.11.006. Epub 2022 Dec 28.
Molecular imaging evaluation of pheochromocytomas and paragangliomas depends on multiple factors, such as localized versus metastatic disease, the genetic, and biochemical profile of tumors. Positron emission tomography/computed tomography (PET/CT) imaging of these tumors outperforms Meta-Iodo-Benzyl-Guanidine (MIBG) scintigraphy in most cases. A few PET radiotracers have been studied in evaluating these patients with somatostatin receptor PET imaging and have shown superior performance compared with other agents in most of these patients. 18F-fluorodeoxyglucose PET/CT imaging is useful in select patients, such as those with succinate dehydrogenase complex subunit B-associated disease. Treatment strategy depends on multiple factors and necessitates a multidisciplinary approach.
嗜铬细胞瘤和副神经节瘤的分子影像学评估取决于多种因素，如局限性或转移性疾病、肿瘤的遗传和生化特征。在大多数情况下，与 Meta-Iodo-Benzyl-Guanidine（MIBG）闪烁显像相比，正电子发射断层扫描/计算机断层扫描（PET/CT）成像在这些肿瘤的成像中表现更好。一些 PET 放射性示踪剂已被用于评估这些患者的生长抑素受体 PET 成像，并在大多数患者中显示出优于其他药物的性能。18F-氟脱氧葡萄糖 PET/CT 成像在某些患者中有用，如琥珀酸脱氢酶复合物亚基 B 相关疾病患者。治疗策略取决于多种因素，需要多学科方法。
