Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Ministry of Health, Colombo, Sri Lanka.
Clin Endocrinol (Oxf). 2023 Apr;98(4):587-602. doi: 10.1111/cen.14874. Epub 2023 Jan 4.
To explore the associations between endogenous testosterone blood concentrations and muscle mass, strength and performance in community dwelling women. DESIGN, PATIENTS AND MEASUREMENTS: Online databases, including Ovid MEDLINE, EMBASE and Web of Science, were searched for observational studies, with at least 100 female participants, reporting associations between endogenous testosterone blood concentrations and muscle mass, strength and performance. The findings were synthesized in a narrative review. Heterogeneity in study design and analysis precluded a meta-analysis.
Of the 36 articles retrieved for full-text review, 10 met the inclusion criteria. Eight studies were cross-sectional, 1 longitudinal and 1 provided both cross-sectional and longitudinal data. Testosterone was measured by liquid chromatography-tandem mass spectrometry in two studies and by immunoassay in 8. An association between total testosterone and muscle mass, strength or performance in women was not found. The studies of calculated free or bioavailable testosterone and lean muscle mass reported a positive association, but no association was reported for muscle strength or performance. Each included study was limited by a high risk of bias in at least one assessed domain.
This review does not support an association between testosterone and muscle mass, strength or performance in women. This, together with the reported associations between free or bioavailable testosterone and muscle mass should be interpreted cautiously due to the predominant use of immunoassay and the inaccuracy of calculated variables. Additionally, biological significance of nonprotein bound testosterone has not been established. Further studies examining the relationship between precisely measured testosterone and muscle mass and function in women are required.
探讨内源性睾酮血浓度与社区居住女性的肌肉量、力量和功能表现之间的关系。
设计、患者和测量：在线数据库，包括 Ovid MEDLINE、EMBASE 和 Web of Science，检索了至少有 100 名女性参与者的观察性研究，报告了内源性睾酮血浓度与肌肉量、力量和功能表现之间的关系。研究结果以叙述性综述的形式进行综合。由于研究设计和分析存在异质性，因此无法进行荟萃分析。
在对全文进行审查后，共检索到 36 篇文章，其中 10 篇符合纳入标准。8 项研究为横断面研究，1 项为纵向研究，1 项提供了横断面和纵向数据。两项研究通过液相色谱-串联质谱法测量睾酮，8 项研究通过免疫测定法测量睾酮。在女性中，未发现总睾酮与肌肉量、力量或功能表现之间存在关联。计算的游离或生物可利用睾酮和瘦肌肉量的研究报告了正相关，但肌肉力量或功能表现没有相关性。每个纳入的研究都存在至少一个评估领域的高偏倚风险。
本综述不支持内源性睾酮与女性肌肉量、力量或功能表现之间存在关联。这一点，以及游离或生物可利用睾酮与肌肉量之间的报告关联，应该谨慎解释，因为主要使用了免疫测定法，并且计算变量存在不准确性。此外，非蛋白结合睾酮的生物学意义尚未确定。需要进一步研究精确测量的睾酮与女性肌肉量和功能之间的关系。
