Department of Dermatology, The Second Affiliated Hospital of Guilin Medical University, 212 Ren-Min Road, Guilin, Guangxi, 541199, China.
Department of Dermatology, The Second Affiliated Hospital of Guilin Medical University, 212 Ren-Min Road, Guilin, Guangxi, 541199, China.
Free Radic Biol Med. 2023 Feb 1;195:158-177. doi: 10.1016/j.freeradbiomed.2022.12.094. Epub 2022 Dec 28.
Imbalance of oxidative stress has been detected in a range of fibrotic diseases. Melatonin as an indoleamine hormone plays an important role in regulating the circadian rhythm of human, while in recent years, its antioxidant effect has also attracted increasing attention. This study aimed to perform a systematic review and meta-analysis to comprehensively evaluate the antioxidant effect of melatonin in animal models of fibrosis.
The PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database (VIP), and SinoMed databases were searched from inception to March 1st, 2022 to retrieve eligible studies that evaluated the effect of melatonin supplementation on the levels of malondialdehyde (MDA), lipid peroxidation (LPO), nitric oxide (NO), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) in animal models of fibrosis.
A total of 64 studies were included in this meta-analysis. The results showed that melatonin supplementation significantly reduced the levels of oxidative indicators including MDA (P < 0.00001), LPO (P < 0.00001) and NO (P < 0.0001), and elevated the levels of antioxidant indicators including GSH (P < 0.00001), GPx (P < 0.00001) and SOD (P < 0.00001) in fibrotic diseases.
Our research findings showed that melatonin supplementation could significantly reduce the levels of oxidative indicators including MDA, LPO and NO and elevate the levels of antioxidant indicators including GSH, GPx and SOD so as to correct oxidative stress in animal models of fibrosis. However, no significant changes were observed in CAT level. More clinical studies are needed to further confirm the beneficial role of melatonin in fibrotic diseases.
氧化应激失衡已在多种纤维化疾病中被检测到。褪黑素作为一种吲哚胺激素，在调节人体昼夜节律方面发挥着重要作用，而近年来，其抗氧化作用也引起了越来越多的关注。本研究旨在进行系统评价和荟萃分析，全面评估褪黑素在纤维化动物模型中的抗氧化作用。
从建库至 2022 年 3 月 1 日，我们检索了 PubMed、Cochrane 图书馆、EMBASE、Web of Science、中国知网（CNKI）、万方数据库、中国科技期刊数据库（VIP）和中国生物医学文献数据库（SinoMed），以检索评估褪黑素补充对纤维化动物模型中丙二醛（MDA）、脂质过氧化（LPO）、一氧化氮（NO）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）水平影响的研究。
共有 64 项研究纳入本荟萃分析。结果显示，褪黑素补充治疗可显著降低氧化指标 MDA（P<0.00001）、LPO（P<0.00001）和 NO（P<0.0001）水平，并升高抗氧化指标 GSH（P<0.00001）、GPx（P<0.00001）和 SOD（P<0.00001）水平。
我们的研究结果表明，褪黑素补充治疗可显著降低 MDA、LPO 和 NO 等氧化指标水平，升高 GSH、GPx 和 SOD 等抗氧化指标水平，从而纠正纤维化动物模型中的氧化应激。然而，CAT 水平无显著变化。需要更多的临床研究进一步证实褪黑素在纤维化疾病中的有益作用。
