胫骨定量超声与双能 X 射线吸收法在早产儿中的比较。
Tibial quantitative ultrasound compared to dual-energy X-ray absorptiometry in preterm infants.
机构信息
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Division of Nephrology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
J Perinatol. 2023 May;43(5):642-646. doi: 10.1038/s41372-022-01588-y. Epub 2022 Dec 31.
OBJECTIVE
The gold standard for diagnosing metabolic bone disease in pediatrics is dual-energy x-ray absorptiometry (DXA). Bone quantitative ultrasound (QUS) has increasing applications. This study compared the relationship of DXA to QUS in preterm infants.
DESIGN
Prospective observational study of preterm infants ≤32 weeks gestation or ≤1800 grams at birth. DXA scans measuring bone mineral content (BMC) and tibial QUS scans measuring bone speed of sound (SOS) were obtained near term gestation.
RESULTS
41 infants had bone scans at mean corrected gestation 37.7 ± 2.1 weeks. BMC and SOS showed weak inverse correlation (R 0.163, p < 0.01). BMC and SOS correlated with parameters at corrected gestational age at the time of the bone scans (p < 0.05-0.001). SOS correlated with birth gestational age (p < 0.001), not BMC.
CONCLUSIONS
A statistically significant weak inverse correlation between DXA and QUS was observed. QUS may have advantages over DXA.
目的
儿科代谢性骨病的金标准诊断方法是双能 X 射线吸收法（DXA）。骨定量超声（QUS）的应用越来越多。本研究比较了 DXA 与 QUS 在早产儿中的相关性。
设计
对胎龄≤32 周或出生体重≤1800 克的早产儿进行前瞻性观察研究。在接近足月妊娠时进行 DXA 扫描测量骨矿物质含量（BMC）和胫骨 QUS 扫描测量骨声速（SOS）。
结果
41 名婴儿在平均校正胎龄 37.7±2.1 周时进行了骨扫描。BMC 和 SOS 呈弱负相关（R 0.163，p<0.01）。BMC 和 SOS 与骨扫描时校正胎龄的参数相关（p<0.05-0.001）。SOS 与出生胎龄相关（p<0.001），与 BMC 无关。
结论
观察到 DXA 和 QUS 之间存在统计学上显著的弱负相关。QUS 可能比 DXA 具有优势。
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