Chaudhary Pradeep Kumar, Gu Juanjuan, Rosen David P, Larson Nicholas B, Brumbaugh Jane E, Fatemi Mostafa, Alizad Azra
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester.
Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905 13 USA.
IEEE Access. 2024;12:106707-106719. doi: 10.1109/access.2024.3437375. Epub 2024 Aug 2.
Despite advances in neonatal care, metabolic bone disease of prematurity (MBDP) remains a common problem in preterm infants. The development of non-invasive and affordable diagnostic approaches can be highly beneficial in the diagnosis and management of preterm infants at risk of MBDP. In this study, we present an ultrasound method called pulsed vibro-acoustic analysis to investigate the progression of bone mineralization in infants over time versus weight and postmenstrual age. The proposed pulsed vibro-acoustic analysis method is used to evaluate the vibrational characteristics of the bone. This method uses the acoustic radiation force of ultrasound to vibrate the bone. The generated acoustic waves are detected using a hydrophone placed on the skin over the tibia. The frequency of vibration and the speeds of received acoustic waves have information regarding the material property of the bone. We examined the feasibility of this method through an in vivo study consisting of 25 preterm and 10 full term infants. The pulsed vibro-acoustic data were acquired longitudinally in preterm infants with multiple visits and at a single visit in full term infants. Speed of sound and mean peak frequency of slow and fast sound waves recorded by hydrophone were used to analyze bone mineralization progress. Linear mixed model was used for statistical analysis in characterizing the mineralization progress in preterm infants compared to data from full term subjects. Significance changes in wave parameters (speed of sound and mean peak frequency) with respect to the postmenstrual age and weight in preterm infants were observed with p-values less than 0.05. Statistical significances in speed of sound measurement for both fast and slow waves were observed between preterm and full term infants, with p-values of <0.01 and 0.02, respectively. The results of this pilot study indicate the potential use of vibro-acoustic analysis for monitoring the progression of bone mineralization in preterm infants.
尽管新生儿护理取得了进展，但早产代谢性骨病（MBDP）仍是早产儿中的常见问题。开发非侵入性且经济实惠的诊断方法对于诊断和管理有MBDP风险的早产儿可能非常有益。在本研究中，我们提出了一种名为脉冲振动声学分析的超声方法，以研究婴儿骨骼矿化随时间与体重及孕龄的进展情况。所提出的脉冲振动声学分析方法用于评估骨骼的振动特性。该方法利用超声的声辐射力使骨骼振动。使用放置在胫骨上方皮肤的水听器检测产生的声波。振动频率和接收到的声波速度包含有关骨骼材料特性的信息。我们通过一项包含25名早产儿和10名足月儿的体内研究检验了该方法的可行性。在早产儿中多次纵向采集脉冲振动声学数据，在足月儿中单次采集。用水听器记录的慢波和快波的声速及平均峰值频率用于分析骨骼矿化进展。与足月儿的数据相比，使用线性混合模型对早产儿的矿化进展进行统计分析。观察到早产儿的波参数（声速和平均峰值频率）相对于孕龄和体重有显著变化，p值小于0.05。在早产儿和足月儿之间观察到快波和慢波声速测量均具有统计学意义，p值分别<0.01和0.02。这项初步研究的结果表明，振动声学分析在监测早产儿骨骼矿化进展方面具有潜在用途。
