运动能力的胚胎发育：来自鸡的启示。
Embryonic Development of Motility: Lessons from the Chicken.
作者信息
Chevalier Nicolas R
机构信息
Laboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, Paris, France.
出版信息
Adv Exp Med Biol. 2022;1383:105-111. doi: 10.1007/978-3-031-05843-1_10.
I outline here the development of intestinal motility in the chicken embryo. The first contractile events are circular smooth muscle driven calcium waves (E6), that gain a clock-like regularity when interstitial cells of Cajal become electrically active (E14). Soon after longitudinal smooth muscle contractions become prominent (E14), the enteric nervous system starts controlling motility (E16) by coupling the longitudinal and circular contractions via inhibitory neurotransmission. It gives rise to circular-longitudinal antagonism, to the migrating motor complex, and to the polarized ascending contraction-descending relaxation pressure response known as the "law of the intestine". The kinetics of gut development in the chicken appears to follow faithfully that of humans by simply converting embryonic days of chicken development into embryonic weeks of human development.
我在此概述鸡胚胎肠道蠕动的发育过程。最初的收缩活动是由环形平滑肌驱动的钙波（胚胎第6天），当 Cajal 间质细胞开始电活动时（胚胎第14天），这些钙波获得类似时钟的规律性。在纵行平滑肌收缩变得显著后不久（胚胎第14天），肠神经系统开始通过抑制性神经传递耦合纵行和环形收缩来控制蠕动（胚胎第16天）。这导致了环形 - 纵行拮抗、移行运动复合体以及被称为“肠道定律”的极化上行收缩 - 下行松弛压力反应。鸡肠道发育的动力学似乎通过简单地将鸡发育的胚胎天数转换为人类发育的胚胎周数，忠实地遵循人类的发育过程。
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