视神经脊髓炎谱系疾病和多发性硬化症患者的智商评估。

Assessment of intelligence quotient in patients with neuromyelitis optica spectrum disease and multiple sclerosis.

作者信息

Ashtari Fereshteh, Manouchehri Navid, Shaygannejad Vahid, Barekatain Majid, Adibi Iman, Afshari-Safavi Alireza, Ramezani Neda, Ghalamkari Arshia, Barzegar Mahdi

机构信息

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX, USA.

出版信息

Mult Scler Relat Disord. 2023 Feb;70:104492. doi: 10.1016/j.msard.2022.104492. Epub 2022 Dec 29.

DOI:10.1016/j.msard.2022.104492

PMID:36587484

Abstract

BACKGROUND

Cognitive impairment is common in people living with neuromyelitis optica spectrum disease (NMOSD) and multiple sclerosis (MS). However, there is little published data on intelligence quotient (IQ) in NMOSD patients. Therefore, we performed the present study to compare IQ scores across NMOSD, MS, and control groups.

METHOD

In this cross-sectional study, 49 NMOSD (30 with positive aquaporin4 antibody), 41 MS, and 20 control individuals were recruited. The IQ score for each person was measured using Wechsler Adult Intelligence Scale-Revised (WAIS-R). Participants were reported on eleven scores of subsets, verbal IQ (VIQ), performance IQ (PIQ), and full score IQ (FSIQ).

RESULT

The scores of FSIQ, VIQ, PIQ, vocabulary, similarities, and digit-symbol in NMOSD and MS individuals were lower than the control group. Relative to control, NMOSD patients reported a lower score of information. We found no difference between NMOSD and MS groups, except in vocabulary and similarities. No significant difference between seropositive and seronegative NMOSD groups was observed except for the information and block design. In NMOSD group, a greater EDSS score was associated with decreased scores of FSIQ, VIQ, and PIQ. Being employed and being married were associated with greater scores of VIQ and PIQ, respectively. In both NMOSD and MS groups, advanced education was associated with increased scores of FSIQ and VIQ.

CONCLUSION

Our study showed decreased IQ scores in NMOSD and MS. Further studies are required to examine intellectual quotient in people with NMOSD and MS.

摘要

背景

认知障碍在视神经脊髓炎谱系疾病（NMOSD）和多发性硬化症（MS）患者中很常见。然而，关于NMOSD患者智商（IQ）的公开数据很少。因此，我们进行了本研究，以比较NMOSD、MS和对照组的IQ分数。

方法

在这项横断面研究中，招募了49例NMOSD患者（30例水通道蛋白4抗体阳性）、41例MS患者和20名对照个体。使用韦氏成人智力量表修订版（WAIS-R）测量每个人的IQ分数。报告了参与者在11个子集分数、言语智商（VIQ）、操作智商（PIQ）和总分智商（FSIQ）方面的情况。

结果

NMOSD和MS个体的FSIQ、VIQ、PIQ、词汇、相似性和数字符号分数低于对照组。相对于对照组，NMOSD患者的信息分数较低。我们发现NMOSD和MS组之间除了词汇和相似性外没有差异。除了信息和积木设计外，血清阳性和血清阴性NMOSD组之间未观察到显著差异。在NMOSD组中，更高的扩展残疾状态量表（EDSS）分数与FSIQ、VIQ和PIQ分数降低相关。就业和已婚分别与更高的VIQ和PIQ分数相关。在NMOSD和MS组中，高等教育都与FSIQ和VIQ分数增加相关。