Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, Malaysia.
Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia.
Int J Pharm. 2023 Feb 5;632:122571. doi: 10.1016/j.ijpharm.2022.122571. Epub 2022 Dec 29.
Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical product's general acceptability is the result of numerous contributing components such as swallowability, palatability (taste, flavour, texture, and mouthfeel), appearance, ease of administration, and patient characteristics. Multiparticulate as a dosage form is a platform technology for overcoming paediatrics' incapacity to swallow monolithic dosage forms, masking many medications' inherent nasty taste, and overcoming the obstacles of manufacturing a commercially taste masked dosage form. This review will discuss the considerations that must be taken into account to prepare taste masked multiparticulate dosage forms in the best way for paediatric use.
味觉是通过舌头上和口腔中的味蕾感知到的感觉。药物的不良味道导致儿科人群拒绝服用药物。众所周知,药品的普遍可接受性是由许多因素共同作用的结果,如可吞咽性、口感(味道、口感、质地和口感)、外观、给药方便性和患者特征。多颗粒剂作为一种剂型,是克服儿科无法吞咽整体剂型、掩盖许多药物固有不良味道以及克服制造商业口味掩蔽剂型的障碍的平台技术。这篇综述将讨论为儿科使用制备掩味多颗粒剂时必须考虑的因素。