Ping Zheng, Li Jinyu, Sun Yawei, Zhang Xiaoli, Wang Ziwen, Cao Xuebin
Department of Cardiology and Nephrology, The 82nd Group Army Hospital of PLA (252 Hospital of PLA), Baoding, Hebei, China.
Chin J Physiol. 2022 Nov-Dec;65(6):290-300. doi: 10.4103/0304-4920.365457.
The effect of different duration of exercise preconditioning (EP) on protecting from exhaustive exercise-induced cardiac injury (EECI) has been optimized in rats. Male Sprague-Dawley rats were divided into six groups: the control group, exhaustive exercise (EE) group, EP 20-min + EE group, EP 40-min + EE group, EP 60-min + EE group and EP 80-min + EE group. The EP groups were subjected to treadmill running at the intensity of 74.0% V̇O. Changes of exercise capacity, cardiac pathology, myocardial enzymology, electrocardiogram (ECG), cardiac function, and mitochondrial respiratory function were compared. Compared to the C group, the EE group has shown significant decrease of exercise capacity, elevation of serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTn-I) levels, cardiac morphology change, ECG disturbance, cardiac dysfunction and reduction of myocardial mitochondrial respiration function. Compared to the EE group, the EP groups have shown significant elevation of exercise capacity, decrease of serum NT-proBNP and cTn-I, improvement of cardiac function and myocardial mitochondrial electron transfer pathway complex I, II and IV activity. The correlation analyses showed protection of EP was proportional to EP duration from 20-min to 60-min. EE caused cardiac injury. EP could protect from EECI by alleviating myocardial damage, improving cardiac function and mitochondrial ETP complex I, II and IV activity. EP protection was positively correlated to EP duration from 20-min to 60-min with EP intensity fixed at 74.0% V̇O.
不同时长运动预处理（EP）对预防力竭运动诱导的心脏损伤（EECI）的作用已在大鼠中得到优化。雄性Sprague-Dawley大鼠被分为六组：对照组、力竭运动（EE）组、EP 20分钟+EE组、EP 40分钟+EE组、EP 60分钟+EE组和EP 80分钟+EE组。EP组以74.0%的摄氧量强度在跑步机上跑步。比较了运动能力、心脏病理学、心肌酶学、心电图（ECG）、心脏功能和线粒体呼吸功能的变化。与C组相比，EE组运动能力显著下降，血清N末端B型利钠肽原（NT-proBNP）和心肌肌钙蛋白I（cTn-I）水平升高，心脏形态改变，心电图紊乱，心脏功能障碍以及心肌线粒体呼吸功能降低。与EE组相比，EP组运动能力显著提高，血清NT-proBNP和cTn-I降低，心脏功能以及心肌线粒体电子传递途径复合物I、II和IV活性得到改善。相关性分析表明，从20分钟到60分钟，EP的保护作用与EP时长成正比。EE导致心脏损伤。EP可通过减轻心肌损伤、改善心脏功能以及线粒体电子传递途径复合物I、II和IV活性来预防EECI。在EP强度固定为74.0%摄氧量的情况下，从20分钟到60分钟，EP的保护作用与EP时长呈正相关。
