Sridaran R, Gibori G
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310-1495.
Placenta. 1987 May-Jun;8(3):327-33. doi: 10.1016/0143-4004(87)90057-9.
Both ovaries and placentae of rats produce androgen in the second half of pregnancy. The objectives of this investigation were to determine whether the pituitary controls both ovarian and placental secretion of testosterone, to find out whether ovarian secretion of testosterone is maintained by the placenta, and to examine whether levels of testosterone produced by the ovaries and placentae depend upon the number of placentae present. Pregnant rats were hypophysectomized with or without hysterectomy in one experiment, and hypophysectomized with or without partial hysterectomy leaving one placenta in situ in another experiment. Testosterone output by the placenta(e) or the ovary was quantified. The results suggest that placental secretion of testosterone is independent of the pituitary between days 12 and 18 of pregnancy, reduction in placental number causes the remaining placenta to compensate by increasing its testosterone output, and ovarian secretion of testosterone may be under placental control between days 12 and 18 of pregnancy.
大鼠的卵巢和胎盘在妊娠后半期都会产生雄激素。本研究的目的是确定垂体是否控制卵巢和胎盘的睾酮分泌，查明胎盘是否维持卵巢的睾酮分泌，并检测卵巢和胎盘产生的睾酮水平是否取决于胎盘数量。在一项实验中，对妊娠大鼠进行垂体切除并伴或不伴子宫切除；在另一项实验中，对妊娠大鼠进行垂体切除并伴或不伴部分子宫切除，仅留一个胎盘在原位。对胎盘或卵巢的睾酮产量进行了量化。结果表明，在妊娠第12至18天期间，胎盘的睾酮分泌独立于垂体，胎盘数量减少会使剩余胎盘通过增加睾酮产量来进行代偿，并且在妊娠第12至18天期间，卵巢的睾酮分泌可能受胎盘控制。
