Galvez E J, Sharma B, Williams F K, You C-J, Khajavi B, Castrillon J, Shi L, Mamani S, Sordillo L A, Zhang L, Alfano R R
Department of Physics and Astronomy, Colgate University, 13 Oak Drive, Hamilton, New York 13346, USA.
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Biomed Opt Express. 2022 Nov 23;13(12):6621-6630. doi: 10.1364/BOE.474469. eCollection 2022 Dec 1.
The generation, manipulation and quantification of non-classical light, such as quantum-entangled photon pairs, differs significantly from methods with classical light. Thus, quantum measures could be harnessed to give new information about the interaction of light with matter. In this study we investigate if quantum entanglement can be used to diagnose disease. In particular, we test whether brain tissue from subjects suffering from Alzheimer's disease can be distinguished from healthy tissue. We find that this is indeed the case. Polarization-entangled photons traveling through brain tissue lose their entanglement via a decohering scattering interaction that gradually renders the light in a maximally mixed state. We found that in thin tissue samples (between 120 and 600 micrometers) photons decohere to a distinguishable lesser degree in samples with Alzheimer's disease than in healthy-control ones. Thus, it seems feasible that quantum measures of entangled photons could be used as a means to identify brain samples with the neurodegenerative disease.
非经典光(如量子纠缠光子对)的产生、操控和量化与经典光的方法有显著不同。因此,量子测量可用于获取有关光与物质相互作用的新信息。在本研究中,我们探究量子纠缠是否可用于疾病诊断。具体而言,我们测试了能否区分阿尔茨海默病患者的脑组织与健康组织。我们发现确实可以。穿过脑组织的偏振纠缠光子通过退相干散射相互作用失去其纠缠,这种相互作用会逐渐使光处于最大混合态。我们发现,在薄组织样本(120至600微米之间)中,与健康对照样本相比,阿尔茨海默病样本中的光子退相干程度较小,仍可区分。因此,纠缠光子的量子测量似乎有可能作为识别患有神经退行性疾病的脑样本的一种手段。