Boccon-Gibod L, Laudat M H, Guiban D, Steg A
Clinique Urologique, Hôpital Cochin, Paris, France.
Prog Clin Biol Res. 1987;243A:45-53.
22 patients with metastatic carcinoma of the prostate were treated by subcapsular orchidectomy and followed by regular determinations of plasma T, DHT, D4A Dione, SDHEA, and TeBG as well as salivary T which measures the free Testosterone. Subcapsular orchidectomy constantly induced a dramatic and stable decrease of testicular androgens or TeBG. Free Testosterone levels vary widely for a given value of plasma T, probably due to individual variations of TeBG. Therefore salivary T should be used preferably to plasma T to monitor hormonal therapy of metastatic carcinoma of the prostate.
22例前列腺转移性癌患者接受了包膜下睾丸切除术，随后定期测定血浆睾酮（T）、双氢睾酮（DHT）、雄烯二酮（D4A Dione）、硫酸脱氢表雄酮（SDHEA）、性激素结合球蛋白（TeBG）以及可测量游离睾酮的唾液睾酮。包膜下睾丸切除术持续导致睾丸雄激素或TeBG显著且稳定地降低。对于给定的血浆T值，游离睾酮水平差异很大，这可能是由于TeBG的个体差异所致。因此，在监测前列腺转移性癌的激素治疗时，唾液T应优先于血浆T使用。
