Kutscher C L
Behavioral Neuroscience Lab., Syracuse University, NY 13244-5070.
Pharmacol Biochem Behav. 1987 Aug;27(4):749-52. doi: 10.1016/0091-3057(87)90203-6.
Four commonly used anorectics which are amphetamine analogues were tested for their action on responsiveness in an acoustic startle test when rats were given daily IP injections adequate to produce a change in body weight. Drugs were given for 22 days. None of these drugs increased startle responsiveness as does the amphetamine parent compound. Instead, fenfluramine and phenylpropanolamine decreased startle responsiveness and phentermine and diethylpropion produced no change. There was no relationship between drug action and body weight. Partial tolerance was found for the fenfluramine action on startle and complete tolerance was found for its action on body weight gain. The fenfluramine action is compatible with the extensive literature on humans and animals indicating sedative properties.
对四种常用的苯丙胺类似物厌食药进行了测试，在大鼠每天腹腔注射足以引起体重变化的剂量时，观察它们对听觉惊吓试验中反应性的影响。药物给药22天。这些药物均未像苯丙胺母体化合物那样增加惊吓反应性。相反，芬氟拉明和苯丙醇胺降低了惊吓反应性，而苯丁胺和二乙丙胺则没有变化。药物作用与体重之间没有关系。发现芬氟拉明对惊吓的作用存在部分耐受性，而对其体重增加的作用存在完全耐受性。芬氟拉明的作用与关于人和动物的大量表明其具有镇静特性的文献相符。
