Cunningham C L, Bischof L L
Oregon Health Sciences University, Portland 97201.
Physiol Behav. 1987;40(3):377-82. doi: 10.1016/0031-9384(87)90064-3.
Three experiments examined the effects of three stressors on the hypothermic response to IP injection of ethanol in rats. Although all three stressors elicited hyperthermia in the absence of ethanol, only electric footshock reduced ethanol hypothermia. Handling/rectal-probing and bright, flashing light enhanced ethanol hypothermia. Type of cage floor (solid vs. grid) affected overall magnitude of ethanol hypothermia, but did not affect handling-induced enhancement of ethanol hypothermia. It is suggested that events which trigger release of endogenous opioids may enhance ethanol hypothermia. This kind of ethanol-stress interaction has important implications for studies of the acute and chronic effects of ethanol, including studies of learned tolerance. It may also have implications for understanding the impact of stress on voluntary consumption of ethanol.
三项实验研究了三种应激源对大鼠腹腔注射乙醇后体温过低反应的影响。尽管在没有乙醇的情况下，所有三种应激源都会引起体温过高，但只有电击足底会降低乙醇引起的体温过低。处理/直肠探查以及明亮闪烁的灯光会增强乙醇引起的体温过低。笼底类型（实心与网格）会影响乙醇引起的体温过低的总体幅度，但不影响处理引起的乙醇体温过低增强效应。研究表明，触发内源性阿片类物质释放的事件可能会增强乙醇引起的体温过低。这种乙醇-应激相互作用对于乙醇急性和慢性影响的研究具有重要意义，包括习得性耐受性的研究。它也可能对理解应激对乙醇自愿消费的影响具有启示作用。
