Peris J, Cunningham C L
Life Sci. 1986 Jan 20;38(3):273-9. doi: 10.1016/0024-3205(86)90313-9.
A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.
轻度应激源（处理）加剧了乙醇对大鼠心率和体温的急性影响。虽然乙醇与处理相结合所产生的心动过速似乎是由于每种情况各自的心动过速效应简单相加所致，但体温变化代表了各自效应的非相加性组合。具体而言，虽然单独处理会产生体温过高，但它增强了乙醇诱导的体温过低。处理并未改变血液和大脑中的乙醇水平。应激诱导的对乙醇关键反应的增强可能对酒精耐受性和依赖性的发展具有重要意义。
