Arends Jann
Klinik für Innere Medizin I, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hugstetter Str. 55, 79106, Freiburg im Breisgau, Deutschland.
Inn Med (Heidelb). 2023 Jan;64(1):10-18. doi: 10.1007/s00108-022-01456-z. Epub 2023 Jan 2.
Nutritional problems occur very frequently in patients with cancer and different problems are associated with separate phases of the disease. Therefore, it is principally recommended to regularly screen all patients with cancer for nutritional disorders and in the case of conspicuous results meticulous diagnostics should be carried to clarify the underlying causes. The focus is on food intake and possible disturbing complaints, the physical performance index, nutritional status including weight change and body composition, the metabolic pattern and the presence of a systemic inflammatory reaction. As anti-cancer treatments frequently induce gastrointestinal derangements which endanger adequate food intake, individualized nutritional care should be offered routinely. After successful curative treatment patients are at risk of developing a metabolic syndrome; therefore, a balanced diet and regular physically activity are recommended. During palliative treatment special attention should be paid to the development of malnutrition. Patients are particularly endangered by cachexia with the combination of inadequate food intake, inactivity and prevailing catabolism. The treatment of cachexia requires a multiprofessional approach to ensure adequate food intake, guiding and supporting physical activity and interventions for normalization of the metabolic situation. In addition, the need for psychological and social support should be discussed. Dietary supplements are of minor relevance; however, deficits in micronutrients, such as vitamins and trace elements need to be balanced. At the end of life, care should primarily be focused on alleviating debilitating symptoms. To reliably support all patients affected by nutritional disorders, clear structures need to be established, responsibilities assigned and standardized procedures codified.
癌症患者经常出现营养问题,不同的问题与疾病的不同阶段相关。因此,主要建议定期对所有癌症患者进行营养紊乱筛查,若结果明显,则应进行细致诊断以明确潜在病因。重点在于食物摄入量和可能的不适主诉、身体活动能力指数、营养状况(包括体重变化和身体成分)、代谢模式以及全身炎症反应的存在情况。由于抗癌治疗常引发胃肠道紊乱,危及充足的食物摄入,因此应常规提供个体化营养护理。在成功进行根治性治疗后,患者有发生代谢综合征的风险;因此,建议均衡饮食并定期进行体育活动。在姑息治疗期间,应特别关注营养不良的发展。患者尤其容易因恶病质而受到威胁,恶病质表现为食物摄入不足、缺乏活动以及普遍存在的分解代谢。恶病质的治疗需要多专业方法,以确保充足的食物摄入、指导和支持体育活动,并采取措施使代谢状况恢复正常。此外,还应讨论心理和社会支持的需求。膳食补充剂的相关性较小;然而,维生素和微量元素等微量营养素的缺乏需要得到平衡。在生命末期,护理应主要侧重于缓解使人虚弱的症状。为了可靠地支持所有受营养紊乱影响的患者,需要建立明确的架构、分配责任并编纂标准化程序。