Department of Clinical Laboratory, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Department of Infectious Disease, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
J Transl Med. 2023 Jan 2;21(1):1. doi: 10.1186/s12967-022-03835-4.
Myeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models. The distribution of MDSCs varies across organs and is divided into three subpopulations: granulocytic MDSCs or polymorphonuclear MDSCs (G-MDSCs or PMN-MDSCs), monocytic MDSCs (M-MDSCs), as well as a recently identified early precursor MDSC (eMDSCs) in humans. Activated MDSCs induce the inactivation of NK cells, CD4+, and CD8+ T cells through a variety of mechanisms, thus promoting the formation of tumor immunosuppressive microenvironment. ER stress plays an important protecting role in the survival of MDSC, which aggravates the immunosuppression in tumors. In addition, ferroptosis can promote an anti-tumor immune response by reversing the immunosuppressive microenvironment. This review summarizes immune suppression by MDSCs with a focus on the role of endoplasmic reticulum stress-mediated immune suppression in cancer and infectious disease, in particular leprosy and tuberculosis.
髓系来源的抑制细胞（MDSCs）是未成熟的异质性骨髓细胞，已被描述为人类和鼠类癌症模型中具有强大免疫调节作用的细胞。MDSCs 在不同器官中的分布不同，可分为三个亚群：粒细胞 MDSC 或多形核 MDSC（G-MDSC 或 PMN-MDSC）、单核细胞 MDSC（M-MDSC），以及人类中最近发现的早期前体细胞 MDSC（eMDSC）。激活的 MDSC 通过多种机制诱导 NK 细胞、CD4+和 CD8+T 细胞失活，从而促进肿瘤免疫抑制微环境的形成。内质网应激在 MDSC 的存活中起着重要的保护作用，这加剧了肿瘤中的免疫抑制。此外，铁死亡通过逆转免疫抑制微环境促进抗肿瘤免疫反应。本综述总结了 MDSC 的免疫抑制作用，重点介绍了内质网应激介导的免疫抑制在癌症和传染病（尤其是麻风病和结核病）中的作用。
