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内质网应激介导与癌症和传染病相关的髓系来源的免疫抑制。

Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease.

机构信息

Department of Clinical Laboratory, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.

Department of Infectious Disease, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.

出版信息

J Transl Med. 2023 Jan 2;21(1):1. doi: 10.1186/s12967-022-03835-4.

DOI:10.1186/s12967-022-03835-4
PMID:36593497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9809056/
Abstract

Myeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models. The distribution of MDSCs varies across organs and is divided into three subpopulations: granulocytic MDSCs or polymorphonuclear MDSCs (G-MDSCs or PMN-MDSCs), monocytic MDSCs (M-MDSCs), as well as a recently identified early precursor MDSC (eMDSCs) in humans. Activated MDSCs induce the inactivation of NK cells, CD4+, and CD8+ T cells through a variety of mechanisms, thus promoting the formation of tumor immunosuppressive microenvironment. ER stress plays an important protecting role in the survival of MDSC, which aggravates the immunosuppression in tumors. In addition, ferroptosis can promote an anti-tumor immune response by reversing the immunosuppressive microenvironment. This review summarizes immune suppression by MDSCs with a focus on the role of endoplasmic reticulum stress-mediated immune suppression in cancer and infectious disease, in particular leprosy and tuberculosis.

摘要

髓系来源的抑制细胞（MDSCs）是未成熟的异质性骨髓细胞，已被描述为人类和鼠类癌症模型中具有强大免疫调节作用的细胞。MDSCs 在不同器官中的分布不同，可分为三个亚群：粒细胞 MDSC 或多形核 MDSC（G-MDSC 或 PMN-MDSC）、单核细胞 MDSC（M-MDSC），以及人类中最近发现的早期前体细胞 MDSC（eMDSC）。激活的 MDSC 通过多种机制诱导 NK 细胞、CD4+和 CD8+T 细胞失活，从而促进肿瘤免疫抑制微环境的形成。内质网应激在 MDSC 的存活中起着重要的保护作用，这加剧了肿瘤中的免疫抑制。此外，铁死亡通过逆转免疫抑制微环境促进抗肿瘤免疫反应。本综述总结了 MDSC 的免疫抑制作用，重点介绍了内质网应激介导的免疫抑制在癌症和传染病（尤其是麻风病和结核病）中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5b/9809056/b0f93edbdfbc/12967_2022_3835_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5b/9809056/07ca5d54753c/12967_2022_3835_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5b/9809056/b0f93edbdfbc/12967_2022_3835_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5b/9809056/07ca5d54753c/12967_2022_3835_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5b/9809056/b0f93edbdfbc/12967_2022_3835_Fig2_HTML.jpg

相似文献

[1]
Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease.

J Transl Med. 2023-1-2

[2]
A common approach for fighting tuberculosis and leprosy: controlling endoplasmic reticulum stress in myeloid-derived suppressor cells.

Immunotherapy. 2021-12

[3]
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer.

J Clin Invest. 2021-8-16

[4]
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Theranostics. 2019-8-12

[5]
The Role of Myeloid-Derived Suppressor Cells in Tumor Growth and Metastasis.

Exp Suppl. 2022

[6]
Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma.

Oncotarget. 2016-6-21

[7]
Accumulation of LOX-1 PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence.

Aging (Albany NY). 2020-12-3

[8]
TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.

Int Immunopharmacol. 2023-11

[9]
ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.

Mol Cancer Res. 2021-4

[10]
An In Vivo Mouse Model for Chronic Inflammation-Induced Immune Suppression: A "Factory" for Myeloid-Derived Suppressor Cells (MDSCs).

Curr Protoc. 2022-9

引用本文的文献

[1]
From mitochondrial dysregulation to ferroptosis: Exploring new strategies and challenges in radioimmunotherapy (Review).

Int J Oncol. 2025-9

[2]
The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells.

Int J Mol Sci. 2025-7-19

[3]
The multi-omics analysis identifies a novel endoplasmic reticulum stress and immune related genes signature in lung adenocarcinoma.

Discov Oncol. 2025-7-1

[4]
Endoplasmic reticulum stress responses in anticancer immunity.

Nat Rev Cancer. 2025-6-24

[5]
Research progress on the cross-regulation between ferroptosis and immunogenic cell death in tumor micro-environment.

Front Oncol. 2025-6-4

[6]
The multifaced role of the macrophage migration inhibitory factor family in organ fibrosis.

Am J Physiol Cell Physiol. 2025-7-1

[7]
Endoplasmic Reticulum Stress in Tuberculosis: Molecular Bases and Pathophysiological Implications in the Immunopathogenesis of the Disease.

Int J Mol Sci. 2025-5-9

[8]
Tumor heterogeneity in retinoblastoma: a literature review.

Cancer Metastasis Rev. 2025-4-22

[9]
The molecular and metabolic landscape of ferroptosis in respiratory diseases: Pharmacological aspects.

J Pharm Anal. 2025-1

[10]
Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults.

Metabolites. 2025-1-23

本文引用的文献

[1]
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production.

Cell Metab. 2022-12-6

[2]
TLR2 agonist promotes myeloid-derived suppressor cell polarization via Runx1 in hepatocellular carcinoma.

Int Immunopharmacol. 2022-10

[3]
Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity.

Eur J Pharmacol. 2022-7-5

[4]
High expression of the ferroptosis-associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma.

J Clin Lab Anal. 2022-4

[5]
Ferroptosis promotes anti-tumor immune response by inducing immunogenic exposure in HNSCC.

Oral Dis. 2023-4

[6]
Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis.

Acta Biomater. 2021-11

[7]
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer.

J Clin Invest. 2021-8-16

[8]
MDSC: Markers, development, states, and unaddressed complexity.

Immunity. 2021-5-11

[9]
The Road of Solid Tumor Survival: From Drug-Induced Endoplasmic Reticulum Stress to Drug Resistance.

Front Mol Biosci. 2021-4-13

[10]
Tumor-related stress regulates functional plasticity of MDSCs.

Cell Immunol. 2021-5

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