Wu Tong, Ji Miaorong, Li Tian, Luo Lianxiang
The First Clinical College, Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
J Pharm Anal. 2025 Jan;15(1):101050. doi: 10.1016/j.jpha.2024.101050. Epub 2024 Jul 24.
Ferroptosis is a form of cell death that occurs when there is an excess of reactive oxygen species (ROS), lipid peroxidation, and iron accumulation. The precise regulation of metabolic pathways, including iron, lipid, and amino acid metabolism, is crucial for cell survival. This type of cell death, which is associated with oxidative stress, is controlled by a complex network of signaling molecules and pathways. It is also implicated in various respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), lung cancer, pulmonary fibrosis (PF), and the coronavirus disease 2019 (COVID-19). To combat drug resistance, it is important to identify appropriate biological markers and treatment targets, as well as intervene in respiratory disorders to either induce or prevent ferroptosis. The focus is on the role of ferroptosis in the development of respiratory diseases and the potential of targeting ferroptosis for prevention and treatment. The review also explores the interaction between immune cell ferroptosis and inflammatory mediators in respiratory diseases, aiming to provide more effective strategies for managing cellular ferroptosis and respiratory disorders.
铁死亡是一种细胞死亡形式，当活性氧（ROS）过量、脂质过氧化和铁积累时发生。包括铁、脂质和氨基酸代谢在内的代谢途径的精确调节对细胞存活至关重要。这种与氧化应激相关的细胞死亡类型由复杂的信号分子和信号通路网络控制。它还与多种呼吸系统疾病有关，如哮喘、慢性阻塞性肺疾病（COPD）、急性肺损伤（ALI）、肺癌、肺纤维化（PF）和2019冠状病毒病（COVID-19）。为了对抗耐药性，识别合适的生物标志物和治疗靶点，以及干预呼吸系统疾病以诱导或预防铁死亡非常重要。重点是铁死亡在呼吸系统疾病发展中的作用以及靶向铁死亡进行预防和治疗的潜力。该综述还探讨了免疫细胞铁死亡与呼吸系统疾病中炎症介质之间的相互作用，旨在为管理细胞铁死亡和呼吸系统疾病提供更有效的策略。
