详细的 [ F]mG4P027 放射性合成作为 mGluR4 的正电子发射断层扫描放射性示踪剂。
Detailed radiosynthesis of [ F]mG4P027 as a positron emission tomography radiotracer for mGluR4.
机构信息
Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Labelled Comp Radiopharm. 2023 Feb;66(2):34-40. doi: 10.1002/jlcr.4011. Epub 2023 Jan 19.
Abstract
We report here the detailed radiosynthesis of [ F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.
摘要
我们在此报告 [ F]mG4P027 的详细放射合成，它是一种代谢型谷氨酸受体 4（mGluR4）正电子发射断层扫描（PET）示踪剂，显示出优于目前报道的 mGluR4 放射性示踪剂的特性。由于自动化系统的放射合成具有挑战性，因此我们在此通过逐步检查来揭示合成的主要限制因素。我们希望这项深入的研究将有助于未来将其自动化用于人体。
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