Moon Sung-Hyun, El Fakhri Georges, Zhang Zhaoda, Brownell Anna-Liisa, Wang Junfeng
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 (USA).
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 (USA).
iRadiology. 2023 Jun;1(2):120-127. doi: 10.1002/ird3.25. Epub 2023 Jun 20.
Fluorine-18 labeled N-(4-chloro-3-(((fluoro-F)methyl-d)thio)phenyl)picolinamide, [F] is a potent positron emission tomography (PET) radiotracer for metabotropic glutamate receptor 4 (mGluR4). Our previous in vitro and in vivo evaluations have demonstrated that this tracer is promising for further translational studies. To automate the radiosynthesis of [F], significant modifications were made to the manual process by carefully examining this process and addressing the root causes of the challenges associated with its automation. We successfully implemented its automated radiosynthesis using the TRACERlab FX2N module and consequently, obtained a high-purity radiolabeled [F] in high yield, meeting the requirements for future human studies.
氟-18标记的N-(4-氯-3-(((氟-F)甲基-d)硫代)苯基)吡啶甲酰胺,[F]是一种用于代谢型谷氨酸受体4(mGluR4)的高效正电子发射断层扫描(PET)放射性示踪剂。我们之前的体外和体内评估表明,这种示踪剂在进一步的转化研究中很有前景。为了实现[F]的放射性合成自动化,通过仔细检查该过程并解决与其自动化相关挑战的根本原因,对手动过程进行了重大改进。我们使用TRACERlab FX2N模块成功实现了其自动化放射性合成,从而以高产率获得了高纯度的放射性标记[F],满足了未来人体研究的要求。