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[血管钙化研究进展与临床实践的共识与争议]

[Consensus and controversy on research progress and clinical practice of vascular calcification].

作者信息

Huang Hui, Zhang Ai-Hua, Chen Jing, Yuan Ling-Qing

机构信息

The Eight Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.

Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

出版信息

Sheng Li Xue Bao. 2022 Dec 25;74(6):859-884.

Abstract

Vascular calcification is an active and complex pathological process regulated by several factors. Vascular calcification is closely related to the incidence and mortality of the cardiovascular disease, chronic kidney disease and other diseases, which affects multiple organs and systems, thus affecting people's health. Therefore, more and more attention is paid to vascular calcification. At present, the pathogenesis and clinical practice of vascular calcification have been continuously improved, which mainly includes calcium and phosphorus imbalance theory, vascular smooth muscle cell transdifferentiation theory, bone homeostasis imbalance theory, epigenetic regulation theory, inflammation theory, extracellular matrix theory, new cell fate theory and so on. However, there are still many unsolved problems. Since the occurrence and development of vascular calcification affect multiple organs and systems, this expert consensus gathered clinicians and basic research experts engaged in the study of vascular calcification in order to summarize the progress of various disciplines related to vascular calcification in recent years. The purpose of this consensus is to systematically summarize the latest research progress, treatment consensus and controversy of vascular calcification from the aspects of epidemiology, pathogenesis, prevention and treatment, so as to provide theoretical basis and clinical enlightenment for in-depth research in this field.

摘要

血管钙化是一个由多种因素调控的活跃且复杂的病理过程。血管钙化与心血管疾病、慢性肾脏病等疾病的发病率及死亡率密切相关,它影响多个器官和系统,进而影响人们的健康。因此,血管钙化越来越受到关注。目前,血管钙化的发病机制及临床实践不断完善,主要包括钙磷失衡理论、血管平滑肌细胞转分化理论、骨稳态失衡理论、表观遗传调控理论、炎症理论、细胞外基质理论、新细胞命运理论等。然而,仍存在许多未解决的问题。由于血管钙化的发生发展影响多个器官和系统,本专家共识汇聚了从事血管钙化研究的临床医生和基础研究专家,旨在总结近年来与血管钙化相关的各学科进展。本共识的目的是从流行病学、发病机制、防治等方面系统总结血管钙化的最新研究进展、治疗共识及争议,为该领域的深入研究提供理论依据和临床启示。

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