Department of Pharmaceutical Sciences, Jharkhand Rai University, Ratu Road, Ranchi, 835222, Jharkhand, India.
Department of Pharmacology, Eminent College of Pharmaceutical Technology, Barasat, 700126, West Bengal, India.
Naunyn Schmiedebergs Arch Pharmacol. 2023 May;396(5):1001-1007. doi: 10.1007/s00210-022-02376-3. Epub 2023 Jan 3.
Breast cancer is the most prevalent diagnosed cancer among women and the main cause of morbidity and mortality. As for breast cancer, MCF-7 cells are an important candidate since they are widely utilized in research for estrogen receptor (ER)-positive breast cancer cell assays, and various sub-clones have been identified to reflect different classes of ER-positive tumors with varied levels of nuclear receptor expression. Rhodamines and its derivatives have shown a great interest over the past two decades due to their excellent structural and spectroscopic properties. Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties. Rhodamine derivatives, in particular, have been widely investigated for their therapeutic properties. In this regard, several studies have shown that rhodamine dye derivatives have promising in vitro and in vivo therapeutic efficacy. The present study deals with potential anticancer activity of few synthesized rhodamine derivatives against MCF-7 cell lines.
乳腺癌是女性中最常见的诊断癌症，也是发病率和死亡率的主要原因。就乳腺癌而言，MCF-7 细胞是一个重要的候选细胞，因为它们广泛应用于研究雌激素受体 (ER) 阳性乳腺癌细胞的测定，并且已经鉴定出各种亚克隆来反映不同类别的 ER 阳性肿瘤，其核受体表达水平不同。近二十年来，由于罗丹明及其衍生物具有优异的结构和光谱性质，因此引起了人们的极大兴趣。罗丹明衍生物因其靶向线粒体和化疗特性而被广泛研究。罗丹明衍生物，特别是其治疗特性，已经得到了广泛的研究。在这方面，几项研究表明，罗丹明染料衍生物具有有前途的体外和体内治疗效果。本研究探讨了几种合成的罗丹明衍生物对 MCF-7 细胞系的潜在抗癌活性。
