Guenard H, Varene N, Vaida P
Laboratoire de Physiologie, UER 3, Université de Bordeaux II, France.
Respir Physiol. 1987 Oct;70(1):113-20. doi: 10.1016/s0034-5687(87)80036-1.
NO and CO lung transfer values (TL) were measured separately in 14 healthy subjects (7 men, 7 women), using the single breath technique. Five repetitive maneuvers were performed by each subject for TLNO and TLCO determinations. The inspired mixture contained either 8 ppm NO or 0.25% CO, with 2% He, 21% O2 in N2. In order to measure an appreciable fraction of NO in the alveolar gas it was necessary to shorten the breath holding time to 3 sec. TLNO was about five times greater than TLCO. This result suggests that the specific conductance of blood (theta) for NO is very high and that the second term of the second member of the equation 1/TLNO = 1/DmNO + 1/(theta NO.Qc) is therefore negligible. DmCO and Qc values can thus be computed from TLNO and TLCO measurements. The results obtained with this method are very close to those reported in the literature; for men DmCO = 79.0 +/- 14.3 ml.min-1.Torr-1, Qc = 78.0 +/- 13.2 ml and for women DmCO = 59.0 +/- 10.1 ml.min-1.Torr-1, Qc = 59.5 +/- 11.6 ml.
采用单次呼吸技术，分别对14名健康受试者（7名男性，7名女性）测量了一氧化氮（NO）和一氧化碳（CO）的肺转移值（TL）。每位受试者进行5次重复操作以测定TLNO和TLCO。吸入混合气含有8 ppm NO或0.25% CO，以及2%氦气、21%氧气，其余为氮气。为了测量肺泡气中可观比例的NO，有必要将屏气时间缩短至3秒。TLNO约为TLCO的5倍。这一结果表明，血液对NO的比电导（θ）非常高，因此方程1/TLNO = 1/DmNO + 1/(θ NO.Qc) 中第二项可以忽略不计。因此，可以根据TLNO和TLCO的测量值计算DmCO和Qc值。用该方法得到的结果与文献报道的结果非常接近；男性的DmCO = 79.0 +/- 14.3 ml.min-1.Torr-1，Qc = 78.0 +/- 13.2 ml；女性的DmCO = 59.0 +/- 10.1 ml.min-1.Torr-1，Qc = 59.5 +/- 11.6 ml。
