Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Department of Geriatric Rehabilitation Medicine, Centre of Rehabilitation Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Medicine (Baltimore). 2022 Dec 30;101(52):e32079. doi: 10.1097/MD.0000000000032079.
Baduanjin is a traditional Chinese exercise regimen used to treat various chronic illnesses and is associated with both psychological and physical benefits. However, its benefits for patients suffering from chronic obstructive pulmonary disease (COPD) are unclear. This study aims to assess the efficacy, safety, and underlying mechanisms of Baduanjin exercise in patients with moderate-to-severe COPD (BROCADE) by remote monitoring.
This study protocol describes a multicenter, open-label, prospective randomized computed tomography. A total of 150 individuals who meet the inclusion criteria after the screening and consent processes will take part in the study. All participants will be provided routine medication and lifestyle interventions. They will be randomly assigned to a control group, a classical pulmonary rehabilitation group, or a Baduanjin group, which will undergo remotely monitored Baduanjin exercises for a cumulative duration of 1 hour per day, three times per week for 12 weeks. The participants will be followed for 24 weeks. The primary outcomes will be a 6-minutes walking distance and St. George's Respiratory Questionnaire index. The secondary outcomes will be lung function, cross-sectional area of the pectoralis major and subcutaneous fat, modified Medical Research Council score, COPD assessment test questionnaire results, extremity muscle strength, and quality of life. Any adverse events that may occur will be monitored and recorded.
This study is ongoing and will be submitted to a peer-reviewed journal for publication once completed.
A novel neutrophil-related inflammatory mechanism will potentially be identified. In addition, the study results will provide a safe, effective, simple and operational Baduanjin exercise protocol for moderate-to-severe COPD patients aimed at improving prognosis and quality of life.
八段锦是一种传统的中国锻炼方法，用于治疗各种慢性病，具有心理和生理上的益处。然而，其对慢性阻塞性肺疾病（COPD）患者的益处尚不清楚。本研究旨在通过远程监测评估八段锦锻炼对中重度 COPD 患者（BROCADE）的疗效、安全性和潜在机制。
本研究方案描述了一项多中心、开放标签、前瞻性随机计算机断层扫描研究。在筛选和同意过程后，符合纳入标准的 150 名个体将参与研究。所有参与者将接受常规药物治疗和生活方式干预。他们将被随机分配到对照组、经典肺康复组或八段锦组，接受远程监测的八段锦锻炼，每天 1 小时，每周 3 次，共 12 周。参与者将随访 24 周。主要结局指标是 6 分钟步行距离和圣乔治呼吸问卷指数。次要结局指标为肺功能、胸大肌和皮下脂肪的横截面积、改良医学研究委员会评分、COPD 评估测试问卷结果、四肢肌肉力量和生活质量。任何可能发生的不良事件都将被监测和记录。
本研究正在进行中，完成后将提交给同行评议期刊发表。
可能会确定一种新的中性粒细胞相关炎症机制。此外，研究结果将为中重度 COPD 患者提供一种安全、有效、简单且可操作的八段锦锻炼方案，旨在改善预后和生活质量。
