From the Department of Pathology (Parkash, Siddon, Panse), Yale University School of Medicine, New Haven, Connecticut.
Department of Pathology, University of California at San Diego, La Jolla, California (Aisagbonhi, Fadare).
Arch Pathol Lab Med. 2023 Oct 1;147(10):1204-1216. doi: 10.5858/arpa.2022-0166-RA.
CONTEXT.—: The World Health Organization Classification of Tumours: Female Genital Tract Tumors, 5th edition, published in September 2020, comes 6 years after the 4th edition, and reflects the monumental leaps made in knowledge about the biology of gynecological tumors. Major changes include revised criteria for the assignment of the site of origin of ovarian and fallopian tube tumors, a revision in the classification of squamous and glandular lesions of the lower genital tract based on human papillomavirus association, and an entire chapter devoted to genetic tumor syndromes. This article highlights the changes in the 5th edition relative to the 4th edition, with a focus on areas of value to routine clinical practice.
OBJECTIVE.—: To provide a comprehensive update on the World Health Organization classification of gynecological tumors, highlighting in particular updated diagnostic criteria and terminology.
DATA SOURCES.—: The 4th and 5th editions of the World Health Organization Classification of Tumours.
CONCLUSIONS.—: The World Health Organization has made several changes in the 5th edition of the update on female genital tumors. Awareness of the changes is needed for pathologists' translation into contemporary practice.
世界卫生组织肿瘤分类：女性生殖器官肿瘤，第 5 版于 2020 年 9 月出版，距第 4 版发布时隔 6 年，反映了在妇科肿瘤生物学知识方面取得的巨大飞跃。主要变化包括对卵巢和输卵管肿瘤起源部位的分类标准进行了修订，根据人乳头瘤病毒的相关性修订了下生殖道的鳞状和腺病变的分类，以及专门用于遗传肿瘤综合征的一章。本文重点介绍了第 5 版相对于第 4 版的变化，特别关注对常规临床实践有价值的领域。
全面更新妇科肿瘤的世界卫生组织分类，特别强调更新的诊断标准和术语。
第 4 版和第 5 版世界卫生组织肿瘤分类。
世界卫生组织在第 5 版女性生殖器官肿瘤更新中做了一些更改。病理学家为将其转化为当代实践，需要了解这些变化。
