Zhang Yue, Feng Jianguo, Ou Cehua, Zhou Xue, Liao Yonghong
Department of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China; Department of Pain Management, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Laboratory of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Behav Brain Res. 2023 Feb 25;440:114282. doi: 10.1016/j.bbr.2022.114282. Epub 2022 Dec 31.
Neuropathic pain is a risk factor for cognitive defects. The ubiquitous expression of AQP4 in astrocytes throughout the central nervous system is altered in the neurodegenerative disease. However, the exact role of AQP4 in cognitive impairment induced by chronic neuropathic pain remains unclear. In this study, we discovered that AQP4 protein and mRNA expression decreased time-dependently in the model of chronic neuropathic pain-induced cognitive disorder. AQP4 overexpression recovered mice from cognitive impairment. Furthermore, the concentration of Aβ1-42 in the serum and hippocampus reduced in mice with AQP4 overexpression adeno-associated virus injection. In conclusion, AQP4 in astrocytes is important in mitigating cognitive impairment caused by chronic neuropathic pain.
神经性疼痛是认知缺陷的一个危险因素。水通道蛋白4（AQP4）在整个中枢神经系统的星形胶质细胞中广泛表达，在神经退行性疾病中会发生改变。然而，AQP4在慢性神经性疼痛引起的认知障碍中的确切作用仍不清楚。在本研究中，我们发现，在慢性神经性疼痛诱导的认知障碍模型中，AQP4蛋白和mRNA表达呈时间依赖性下降。AQP4过表达使小鼠从认知障碍中恢复。此外，注射AQP4过表达腺相关病毒的小鼠血清和海马中β淀粉样蛋白1-42（Aβ1-42）的浓度降低。总之，星形胶质细胞中的AQP4在减轻慢性神经性疼痛引起的认知障碍方面很重要。
