Medical School of Chinese PLA, Beijing 100853, China;Department of Stomatology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, China.
Biomed Environ Sci. 2022 Dec 20;35(12):1115-1125. doi: 10.3967/bes2022.141.
To develop an effective treatment strategy to simultaneously avoid fatal adverse effects in the treatment of oral cancer, combination therapy has been explored because of its multiple functions. This work aims to develop a novel type of gold-nanorod-based nanomaterials decorated with tetrahedral DNA nanostructures (TDN) carrying antitumor drugs, namely, GNR@TDN-DOX nanocomposites.
In the designed structure, TDN, with a three-dimensional geometry composed of DNA strands, can provide GC base pairs for binding with the anticancer drug doxorubicin (DOX). The photothermal heating properties, biocompatibility properties, and antitumor performance of obtained GNR@TDN-DOX nanocomposites were investigated to assess their application potential in tumor treatment.
Systematic studies have shown that the obtained GNR@TDN-DOX nanocomposites have high photothermal conversion under the illumination of an 808-nm infrared laser, leading to effective antitumor applications. In addition, the cell viability study shows that GNR@TDN-DOX nanocomposites have good biocompatibility. studies based on A375 cells show that the GNR@TDN-DOX nanocomposites can effectively eliminate cancer cells because of the combination of photothermal therapy induced by GNRS and chemotherapy induced by TDN-carrying DOX. The result shows that the obtained GNR@TDN-DOX nanocomposites have efficient cellular uptake and lysosome escape ability, together with their nuclear uptake behavior, which results in a significant antitumor effect.
This work has demonstrated a potential nanoplatform for anticancer applications.
为了开发一种有效的治疗策略，同时避免口腔癌治疗中的致命不良反应，由于其多种功能，已经探索了联合治疗。本工作旨在开发一种新型的基于金纳米棒的纳米材料，该纳米材料用携带抗肿瘤药物的四面体 DNA 纳米结构（TDN）进行了修饰，即 GNR@TDN-DOX 纳米复合材料。
在设计的结构中，TDN 由 DNA 链组成的三维几何形状，可以为结合抗肿瘤药物阿霉素（DOX）提供 GC 碱基对。研究了所获得的 GNR@TDN-DOX 纳米复合材料的光热加热特性、生物相容性和抗肿瘤性能，以评估它们在肿瘤治疗中的应用潜力。
系统研究表明，所获得的 GNR@TDN-DOX 纳米复合材料在 808nm 红外激光照射下具有高光热转换效率，从而实现了有效的抗肿瘤应用。此外，细胞活力研究表明 GNR@TDN-DOX 纳米复合材料具有良好的生物相容性。基于 A375 细胞的研究表明，由于 GNRS 诱导的光热治疗和 TDN 携带 DOX 诱导的化学治疗的结合，GNR@TDN-DOX 纳米复合材料可以有效地消除癌细胞。结果表明，所获得的 GNR@TDN-DOX 纳米复合材料具有高效的细胞摄取和溶酶体逃逸能力，以及它们的核摄取行为，从而产生显著的抗肿瘤效果。
这项工作展示了一种用于抗癌应用的潜在纳米平台。
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