Chen Yuwen, Cai Sijia, Liu Fa-Yu, Liu Ming
Departmentof Orthodontics, School of Stomatology, China Medical University, 117 South Nanjing Street, Heping, Shenyang, Liaoning, 110002, P.R. China.
Department of Oromaxillofacial-Head and Neck, Oral Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning, 110002, P.R. China.
Cell Biol Toxicol. 2025 May 23;41(1):90. doi: 10.1007/s10565-025-10027-5.
The advent of nanotechnology has significantly advanced the diagnosis and treatment of oral cancer, offering more precise and efficient therapeutic strategies. This review presents a comprehensive overview of recent developments in the application of nanotechnology to oral cancer management. It begins with an overview of the epidemiology of oral cancer and outlines current diagnostic and therapeutic methods. The classification and advantages of various nanomaterials are then introduced. The paper thoroughly explores the use of nanomaterials as drug delivery systems (DDSs), imaging contrast agents, and therapeutic tools, with particular emphasis on multifunctional nanoplatforms that integrate diagnostics and therapy. These platforms enable real-time monitoring and immediate therapeutic response, offering innovative approaches for early detection and intervention. Despite these promising advances, several challenges persist, including issues related to biocompatibility, clearance, targeting specificity, and clinical translation. The review concludes by highlighting current limitations and proposing future directions for the clinical application of nanotechnology in oral cancer treatment.
纳米技术的出现显著推动了口腔癌的诊断和治疗，提供了更精确、高效的治疗策略。本文综述全面概述了纳米技术在口腔癌治疗应用中的最新进展。首先概述了口腔癌的流行病学，并简述了当前的诊断和治疗方法。接着介绍了各种纳米材料的分类和优点。本文深入探讨了纳米材料作为药物递送系统（DDS）、成像造影剂和治疗工具的应用，尤其着重于整合诊断与治疗的多功能纳米平台。这些平台能够实现实时监测并立即进行治疗反应，为早期检测和干预提供了创新方法。尽管取得了这些有前景的进展，但仍存在一些挑战，包括与生物相容性、清除、靶向特异性以及临床转化相关的问题。综述最后强调了当前的局限性，并提出了纳米技术在口腔癌治疗临床应用的未来方向。
