他汀类药物与癌症预防——关联并不意味着因果关系。
Statins and Cancer Prevention-Association Does Not Mean Causation.
机构信息
Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Urology, University of California - Los Angeles, Los Angeles, California.
出版信息
Cancer Prev Res (Phila). 2023 Jan 4;16(1):1-3. doi: 10.1158/1940-6207.CAPR-22-0420.
Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have anticancer activities. However, clinical studies investigating the association between statin usage and cancer development have been few and inconsistent. A recent study from Maeda-Minami and colleagues found a significant, though modest, decrease in cancer risk among statin users. However, does this finding mean statin usage directly reduces cancer risk or is merely associated with reduced cancer risk? This editorial analyzes Maeda-Minami and colleagues' study to provide commentary on statin's proposed role in preventing cancer. See related article, p. 37.
他汀类药物是广泛应用的药物，可抑制 3-羟基-3-甲基戊二酰辅酶 A（HMG CoA）还原酶，从而减少胆固醇的合成。鉴于胆固醇在癌症中的关键作用，他汀类药物可能具有抗癌活性。然而，研究他汀类药物使用与癌症发展之间关系的临床研究很少且结果不一致。最近，前田美波和同事的一项研究发现，他汀类药物使用者的癌症风险显著降低，尽管幅度不大。然而，这一发现是否意味着他汀类药物的使用直接降低了癌症风险，还是仅仅与降低癌症风险有关？这篇社论分析了前田美波和同事的研究，就他汀类药物在预防癌症方面的作用提供了评论。详见相关文章第 37 页。
Zotero 插件