Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
J Med Virol. 2023 Feb;95(2):e28455. doi: 10.1002/jmv.28455.
Traditional observational studies have suggested a potential association between trans fatty acids (TFAs), which are considered to be health-damaging fatty acids, and coronavirus disease 2019 (COVID-19). However, whether there is a causal relationship between them is currently unclear. We aimed to investigate the causal link between genetically determined TFAs and COVID-19. We performed univariate and multivariate Mendelian randomization (MR) studies using summary statistics from the European Pedigree TFAs (n = 8013), COVID-19 susceptibility (n = 159 840), COVID-19 hospitalization (n = 44 986), and COVID-19 severity (n = 18 152) genome-wide association studies (GWAS). The inverse variance weighted (IVW) method was used as the primary MR analysis, and several other methods were used as supplements. In univariate MR analysis, higher levels of circulating trans, cis-18:2 TFAs were positively associated with a higher COVID-19 hospitalization rate (p < 0.0033; odds ratio [OR] = 1.637; 95% confidence interval [CI]: 1.116-2.401) and COVID-19 severity (p < 0.0033; OR = 2.575; 95% CI: 1.412-4.698). Furthermore, in multivariate MR analysis, trans, cis-18:2 had an independent and significant causal association with a higher COVID-19 hospitalization rate (p = 0.00044; OR = 1.862; 95% CI = 1.316-2.636) and COVID-19 severity (p = 0.0016; OR = 2.268; 95% CI = 1.361-3.779) after the five TFAs were adjusted for each other. Together, our findings provide evidence that trans, cis-18:2 TFAs have an independent and robust causal effect on COVID-19 hospitalization and severity.
传统的观察性研究表明，反式脂肪酸（被认为对健康有害的脂肪酸）与 2019 年冠状病毒病（COVID-19）之间可能存在关联。然而，它们之间是否存在因果关系尚不清楚。我们旨在研究遗传决定的反式脂肪酸与 COVID-19 之间的因果关系。我们使用来自欧洲家族性反式脂肪酸（n=8013）、COVID-19 易感性（n=159840）、COVID-19 住院（n=44986）和 COVID-19 严重程度（n=18152）全基因组关联研究（GWAS）的汇总统计数据，进行了单变量和多变量孟德尔随机化（MR）研究。反向方差加权（IVW）方法作为主要的 MR 分析，还使用了其他几种方法作为补充。在单变量 MR 分析中，循环中转式，顺式-18：2 反式脂肪酸水平升高与 COVID-19 住院率升高呈正相关（p<0.0033；比值比[OR] = 1.637；95%置信区间[CI]：1.116-2.401）和 COVID-19 严重程度（p<0.0033；OR = 2.575；95% CI：1.412-4.698）。此外，在多变量 MR 分析中，转式，顺式-18：2 与 COVID-19 住院率升高（p=0.00044；OR=1.862；95% CI=1.316-2.636）和 COVID-19 严重程度（p=0.0016；OR=2.268；95% CI=1.361-3.779）具有独立且显著的因果关系，在调整了其他 5 种反式脂肪酸后。综上所述，我们的研究结果提供了证据表明，转式，顺式-18：2 反式脂肪酸对 COVID-19 住院和严重程度具有独立且稳健的因果影响。
