一名成人的慢性肉芽肿病。

Chronic granulomatous disease in an adult.

作者信息

Nerurkar L S, Jacob A, Zeligs B, Walser J, Yeager H, Bellanti J A

机构信息

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.

出版信息

South Med J. 1987 Oct;80(10):1296-302. doi: 10.1097/00007611-198710000-00022.

DOI:10.1097/00007611-198710000-00022

PMID:3660045

Abstract

We have described a 49-year-old man with chronic granulomatous disease. The diagnosis was established by a deficiency of NBT dye reduction by neutrophils, in addition to impairment in 14C-1-glucose utilization, 125I-iodination of zymosan, chemiluminescence, superoxide radical generation, and bactericidal activity toward S aureus. This adult patient exhibits many characteristics of chronic granulomatous disease of childhood but of less severity, which may explain his unusually long survival. It is thus important to consider the diagnosis of chronic granulomatous disease not only in children but also in adult patients having the characteristic pattern of recurrent infections.

摘要

我们描述了一名患有慢性肉芽肿病的49岁男性。除了14C - 1 -葡萄糖利用受损、酵母聚糖的125I碘化、化学发光、超氧自由基生成以及对金黄色葡萄球菌的杀菌活性受损外，通过中性粒细胞对NBT染料还原能力的缺乏确诊该病。这名成年患者表现出许多儿童慢性肉芽肿病的特征，但症状较轻，这可能解释了他异常长的生存期。因此，不仅在儿童中，而且在具有反复感染特征模式的成年患者中考虑慢性肉芽肿病的诊断都很重要。