SIX4 通过上调 IDH1 和代谢重编程促进骨肉瘤进展。
SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression.
机构信息
Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Orthopaedics, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.
出版信息
J Cell Mol Med. 2023 Jan;27(2):259-265. doi: 10.1111/jcmm.17650. Epub 2023 Jan 4.
Metabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the role of SIX4 in osteosarcoma progression remains unknown. The expression profile of SIX4 in OS was evaluated in surgery samples of osteosarcoma patients. Functional studies were performed in vitro and in vivo. We found that SIX4 is significantly overexpressed in osteosarcoma and related to the undesirable prognosis of osteosarcoma patients. SIX4 promotes progression of osteosarcoma via upregulating isocitrate dehydrogenase 1 (IDH1), which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.
代谢重编程在肿瘤发生和骨肉瘤转移中起着重要作用。Sine oculis 同源盒 4（SIX4）被报道为参与癌细胞糖酵解重编程的关键转录因子。然而，SIX4 在骨肉瘤进展中的作用尚不清楚。在骨肉瘤患者的手术样本中评估了 SIX4 在 OS 中的表达谱。在体外和体内进行了功能研究。我们发现 SIX4 在骨肉瘤中显著过表达，并与骨肉瘤患者的不良预后相关。SIX4 通过上调异柠檬酸脱氢酶 1（IDH1）促进骨肉瘤的进展，为骨肉瘤患者提供了新的预后生物标志物和有前途的治疗靶点。
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