高价态 Cu(III)-CF 化合物介导的酯化反应。
High-valent Cu(III)-CF compound-mediated esterification reaction.
机构信息
School of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, Xinjiang, China.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China.
出版信息
Org Biomol Chem. 2023 Feb 1;21(5):935-939. doi: 10.1039/d2ob02166h.
Cu(III)-CF compounds are reported herein as novel coupling reagents to mediate ester synthesis from carboxyl acids and alcohols/phenols. Carboxylic acids are transformed to trifluoromethyl ester and acyl fluoride activated species that interact with each other. The broad substrate scope and late-stage application of this method are demonstrated. This study opens up new opportunities to develop interesting reactions using Cu(III)-CF compounds without transferring a CF group to the products.
本文报道了 Cu(III)-CF 化合物作为新型偶联试剂，用于介导羧酸和醇/酚的酯化反应。羧酸被转化为三氟甲酯和酰氟活化物种，它们相互作用。该方法具有广泛的底物范围和后期应用，证明了这一点。这项研究为使用 Cu(III)-CF 化合物开发有趣的反应提供了新的机会，而无需将 CF 基团转移到产物中。
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