Yvernogeau Laurent, Dainese Giovanna, Jaffredo Thierry
Sorbonne Université, IBPS, CNRS UMR7622, Inserm U1156, Laboratoire de Biologie du Développement, 75005 Paris, France.
Development. 2023 Jan 1;150(1). doi: 10.1242/dev.201173. Epub 2023 Jan 5.
Recent studies have highlighted the crucial role of the aorta microenvironment in the generation of the first haematopoietic stem cells (HSCs) from specialized haemogenic endothelial cells (HECs). Despite more than two decades of investigations, we require a better understanding of the cellular and molecular events driving aorta formation and polarization, which will be pivotal to establish the mechanisms that operate during HEC specification and HSC competency. Here, we outline the early mechanisms involved in vertebrate aorta formation by comparing four different species: zebrafish, chicken, mouse and human. We highlight how this process, which is tightly controlled in time and space, requires a coordinated specification of several cell types, in particular endothelial cells originating from distinct mesodermal tissues. We also discuss how molecular signals originating from the aorta environment result in its polarization, creating a unique entity for HSC generation.
最近的研究强调了主动脉微环境在从特殊造血内皮细胞（HECs）产生首批造血干细胞（HSCs）过程中的关键作用。尽管经过了二十多年的研究，但我们仍需要更好地理解驱动主动脉形成和极化的细胞及分子事件，这对于确立在造血内皮细胞特化和造血干细胞能力形成过程中起作用的机制至关重要。在此，我们通过比较四种不同物种：斑马鱼、鸡、小鼠和人类，概述脊椎动物主动脉形成所涉及的早期机制。我们强调了这个在时间和空间上受到严格控制的过程是如何需要几种细胞类型的协同特化，特别是源自不同中胚层组织的内皮细胞。我们还讨论了源自主动脉环境的分子信号如何导致其极化，从而为造血干细胞的产生创造一个独特的实体。
