多囊肾病中致病基因的转录编程

Transcriptional programming of pathogenic genes in polycystic kidney disease.

作者信息

Ko Je Yeong, Park Jong Hoon

机构信息

Department of Biological Science, Sookmyung Women's University, Seoul, Korea.

出版信息

Kidney Int. 2023 Jan;103(1):25-28. doi: 10.1016/j.kint.2022.10.022.

DOI:10.1016/j.kint.2022.10.022

PMID:36603979

Abstract

Transcriptional dysregulation is a prominent contributor to the pathogenesis of autosomal dominant polycystic kidney disease. Lakhia et al. identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst formation. This commentary discusses these findings reported by Lakhia et al. in the broader contexts of transcriptional programming and the identification of potential autosomal dominant polycystic kidney disease therapeutic targets.

摘要

转录失调是常染色体显性多囊肾病发病机制的一个主要促成因素。拉希亚等人确定了与疾病基因相关的增强子景观及其在常染色体显性多囊肾病中的病理作用，以了解囊肿形成。本述评在转录编程和潜在的常染色体显性多囊肾病治疗靶点识别的更广泛背景下讨论了拉希亚等人报告的这些发现。