Valois A A, Webster W S
Department of Anatomy, University of Sydney, NSW, Australia.
Toxicology. 1987 Oct 12;46(1):43-55. doi: 10.1016/0300-483x(87)90136-3.
The relationship between postnatal age at time of cadmium (Cd) exposure, and the retention and distribution of Cd in the central nervous system (CNS) was studied using gamma counting and autoradiography. A single intraperitoneal dose of Cd2+ (84 micrograms/kg or 750 micrograms/kg) containing radioactive 109Cd, was administered on postnatal day 0, 7, 14, or 42. Animals were then killed at various times post exposure (1-115 days) and retention and distribution determined. Maximum retention of Cd in the brain (calculated as a percentage of administered dose) occurred 1-24 days after exposure. Following exposure on day 0, 7, 14, or 42, maximum retention was 1.2%, 1.6%, 0.4%, or 0.09%, respectively. Cd retention after 114 days was 0.3%, 1.0%, 0.1%, or 0.04% for the respective days of exposure. For the carrier-added group maximum retention was higher with corresponding figures of 2.3%, 1.6%, 1.4%, or 0.07% and retention after 114 days was also elevated 0.6%, 1.1%, 0.4%, or 0.04%. The autoradiographic studies indicated that the choroid plexus was the prime target for Cd uptake in the CNS for all age groups, with the blood vessels a target in the early postnatal period.
采用γ计数和放射自显影技术，研究了镉（Cd）暴露时的出生后年龄与Cd在中枢神经系统（CNS）中的潴留和分布之间的关系。在出生后第0、7、14或42天，经腹腔单次注射含放射性109Cd的Cd2+（84微克/千克或750微克/千克）。然后在暴露后的不同时间点（1 - 115天）处死动物，并测定潴留和分布情况。Cd在脑中的最大潴留量（以给药剂量的百分比计算）在暴露后1 - 24天出现。在出生后第0、7、14或42天暴露后，最大潴留量分别为1.2%、1.6%、0.4%或0.09%。暴露114天后，相应暴露日的Cd潴留量分别为0.3%、1.0%、0.1%或0.04%。对于添加载体的组，最大潴留量更高，相应数字分别为2.3%、1.6%、1.4%或0.07%，114天后的潴留量也有所升高，分别为0.6%、1.1%、0.4%或0.04%。放射自显影研究表明，脉络丛是所有年龄组CNS中Cd摄取的主要靶点，在出生后早期血管也是靶点。
