Blériot Camille, Dalmas Élise, Ginhoux Florent, Venteclef Nicolas
Institut Necker-Enfants Malades (INEM), Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France.
Institut Necker-Enfants Malades (INEM), Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Paris, France.
Trends Immunol. 2023 Feb;44(2):101-109. doi: 10.1016/j.it.2022.12.004. Epub 2023 Jan 3.
Type 2 diabetes (T2D) represents a global threat affecting millions of patients worldwide. However, its causes remain incompletely dissected and we lack the tools to predict which individuals will develop T2D. Although there is a clear proven clinical association of T2D with metabolic disorders such as obesity and nonalcoholic fatty liver disease (NAFLD), the existence of a significant number of nondiabetic obese subjects suggests yet-uncovered features of such relationships. Here, we propose that a significant proportion of individuals may harbor an immune profile that renders them susceptible to developing T2D. We note the heterogeneity of circulating monocytes and tissue macrophages in organs that are key to metabolic disorders such as liver, white adipose tissue (WAT), and endocrine pancreas, as well as their contribution to T2D genesis.
2型糖尿病（T2D）是一种全球性威胁，影响着全球数百万患者。然而，其病因仍未完全明确，我们也缺乏预测哪些个体将患T2D的工具。尽管T2D与肥胖和非酒精性脂肪性肝病（NAFLD）等代谢紊乱之间存在明确的临床关联，但大量非糖尿病肥胖受试者的存在表明这种关系还有尚未被发现的特征。在此，我们提出相当一部分个体可能具有使其易患T2D的免疫特征。我们注意到在肝脏、白色脂肪组织（WAT）和内分泌胰腺等对代谢紊乱至关重要的器官中循环单核细胞和组织巨噬细胞的异质性，以及它们对T2D发生的作用。
