铅毒性对雏鸡体内谷胱甘肽及谷胱甘肽相关游离氨基酸器官浓度的影响。

Effect of lead toxicity on the organ concentration of glutathione and glutathione-related free amino acids in the chick.

作者信息

McGowan C, Donaldson W E

机构信息

Food Science and Human Nutrition Department, University of Florida, Gainesville 32611.

出版信息

Toxicol Lett. 1987 Oct;38(3):265-70. doi: 10.1016/0378-4274(87)90007-5.

DOI:10.1016/0378-4274(87)90007-5

PMID:3660429

Abstract

Total non-protein sulfhydryl (NPSH) and glutathione (GSH) concentrations in liver and kidney and GSH-related free amino acid concentrations in liver, kidney and plasma were examined in the chick following intoxication with 2000 ppm dietary lead (Pb). After 3 weeks, NPSH content was significantly (P less than 0.05) increased by Pb in both liver and kidney while only liver GSH was increased by Pb treatment. The concentrations of glutamate, glycine and methionine were elevated in liver by Pb while glycine, cysteine and cystathionine concentrations were increased in the kidney. In plasma, Pb significantly decreased cysteine, taurine and cystathionine concentrations.

摘要

在用2000 ppm膳食铅（Pb）使雏鸡中毒后，检测了肝脏和肾脏中的总非蛋白巯基（NPSH）和谷胱甘肽（GSH）浓度，以及肝脏、肾脏和血浆中与GSH相关的游离氨基酸浓度。3周后，肝脏和肾脏中的NPSH含量均因铅而显著（P<0.05）增加，而仅肝脏中的GSH因铅处理而增加。铅使肝脏中的谷氨酸、甘氨酸和蛋氨酸浓度升高，而肾脏中的甘氨酸、半胱氨酸和胱硫醚浓度增加。在血浆中，铅显著降低了半胱氨酸、牛磺酸和胱硫醚浓度。