关于雄性F-344大鼠肠道微生物群在1,3-二硝基苯诱导的中枢神经系统毒性中所起作用的初步研究。
Preliminary investigations into the involvement of the intestinal microflora in CNS toxicity induced by 1,3-dinitrobenzene in male F-344 rats.
作者信息
Philbert M A, Gray A J, Connors T A
机构信息
Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, U.K.
出版信息
Toxicol Lett. 1987 Oct;38(3):307-14. doi: 10.1016/0378-4274(87)90013-0.
PMID:3660433
Abstract
Administration of a single oral dose of 20 mg/kg of 1,3-dinitrobenzene caused ataxia in germ-free male F-344 rats but not in conventional rats. Repeated oral dosing of 20 mg/kg, 1,3-DNB was required to cause ataxia in conventional rats. Considerable differences were observed between the uptake, tissue distribution and excretion of DNB in germ-free and conventional rats.
摘要
给无菌雄性F - 344大鼠单次口服20毫克/千克的1,3 - 二硝基苯会导致共济失调，但对普通大鼠则不会。普通大鼠需要重复口服20毫克/千克的1,3 - 二硝基苯才会导致共济失调。在无菌大鼠和普通大鼠中，观察到二硝基苯在摄取、组织分布和排泄方面存在相当大的差异。
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