Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai, 200000, China.
Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Sci Data. 2023 Jan 5;10(1):13. doi: 10.1038/s41597-022-01925-y.
Explosive blast-related traumatic brain injuries (bTBI) are common in war zones and urban terrorist attacks. These bTBIs often result in complex neuropathologic damage and neurologic complications. However, there is still a lack of specific strategies for diagnosing and/or treating bTBIs. The sub-ventricular zone (SVZ), which undergoes adult neurogenesis, is critical for the neurological maintenance and repair after brain injury. However, the cellular responses and mechanisms that trigger and modulate these activities in the pathophysiological processes following bTBI remain poorly understood. Here we employ single-nucleus RNA-sequencing (snRNA-seq) of the SVZ from mice subjected to a bTBI. This data-set, including 15272 cells (7778 bTBI and 7494 control) representing all SVZ cell types and is ideally suited for exploring the mechanisms underlying the pathogenesis of bTBIs. Additionally, it can serve as a reference for future studies regarding the diagnosis and treatment of bTBIs.
爆炸相关的创伤性脑损伤（bTBI）在战区和城市恐怖袭击中很常见。这些 bTBIs 常导致复杂的神经病理学损伤和神经并发症。然而，目前仍然缺乏用于诊断和/或治疗 bTBIs 的特定策略。室下区（SVZ）经历成人神经发生，对于脑损伤后的神经维持和修复至关重要。然而，在 bTBI 后的病理生理过程中，触发和调节这些活动的细胞反应和机制仍知之甚少。在这里，我们对接受 bTBI 的小鼠的 SVZ 进行了单细胞 RNA 测序（snRNA-seq）。这个数据集包括 15272 个细胞（7778 个 bTBI 和 7494 个对照），代表所有 SVZ 细胞类型，非常适合探索 bTBIs 发病机制的机制。此外，它可以作为未来关于 bTBIs 的诊断和治疗研究的参考。
