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未行切除的情况下，尿路上皮癌的派杰样扩散得到控制。

Pagetoid spread of urothelial carcinoma controlled without resection.

作者信息

Yamamoto Shutaro, Shimomura Tatsuya, Kasai Kanako, Yamazaki Taisuke, Enei Yuki, Koike Yusuke, Ito Toshihiro, Harada Tohru, Furuta Nozomu, Kimura Takahiro

机构信息

Department of Urology The Jikei University Daisan Hospital Komae Tokyo Japan.

Department of Urology JR Tokyo General Hospital Shibuya Tokyo Japan.

出版信息

IJU Case Rep. 2022 Nov 6;6(1):65-69. doi: 10.1002/iju5.12555. eCollection 2023 Jan.

DOI:10.1002/iju5.12555
PMID:36605693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9807350/
Abstract

INTRODUCTION

Extramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion.

CASE PRESENTATION

An 80-year-old woman with a 7-year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first-line platinum-based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease.

CONCLUSION

Platinum-based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma.

摘要

引言

乳房外佩吉特病是一种影响外阴和会阴的湿疹样皮肤病。继发于尿路上皮癌的乳房外佩吉特病是一种罕见疾病，通常采用病变的侵入性手术切除进行治疗。

病例介绍

一名患有7年尿路上皮癌病史的80岁女性出现大阴唇红斑。皮肤活检标本的免疫染色提示继发于尿路上皮癌的乳房外佩吉特病。患者不同意切除病变。对转移性尿路上皮癌进行了9个周期的一线铂类化疗。由于全身化疗后仍有肿瘤细胞残留，将对该患者使用帕博利珠单抗治疗残留的乳房外佩吉特病。

结论

铂类化疗可控制继发于尿路上皮癌的乳房外佩吉特病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/5a765b3a35e4/IJU5-6-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/8831395a62fc/IJU5-6-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/c9c267cfd8bd/IJU5-6-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/5a765b3a35e4/IJU5-6-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/8831395a62fc/IJU5-6-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/c9c267cfd8bd/IJU5-6-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f81/9807350/5a765b3a35e4/IJU5-6-65-g003.jpg

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Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation.
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