Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, I. R. Iran.
Dalton Trans. 2023 Jan 31;52(5):1257-1267. doi: 10.1039/d2dt03021g.
The aim of this study has been to offer a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on green chemistry principles. Therefore, a one-pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate and 1,2-diketone under solvent-free conditions was utilized as an eco-effective synthetic route using CoFeO@SiO@(-CH)OWOH NPs as the catalyst. The stabilized tungstic acid on 3-chloropropyl-anchored SiO-coated CoFeO magnetic nanoparticles was designed, prepared, and applied as a recyclable heterogeneous acid catalyst to attain high product yield in a short reaction time. The nanocatalyst structure was confirmed using FT-IR, Raman, XRD, FE-SEM, EDX, VSM, and TGA techniques, and the organic product structures were examined by melting point, FT-IR and H NMR analyses.
本研究旨在提供一种基于绿色化学原理合成 2,4,5-三取代咪唑衍生物的方法。因此，我们采用了一种无溶剂条件下通过醛与乙酸铵和 1,2-二酮的一锅多组分环缩合反应，利用 CoFeO@SiO@(-CH)OWOH NPs 作为催化剂，这是一种生态有效的合成路线。我们设计、制备并应用了稳定的杂多酸负载在 3-氯丙基锚定的 SiO2 包覆的 CoFeO 磁性纳米颗粒上，作为一种可回收的多相酸催化剂，以在短反应时间内获得高产率的有机产物。纳米催化剂的结构通过傅里叶变换红外光谱（FT-IR）、拉曼光谱、X 射线衍射（XRD）、场发射扫描电子显微镜（FE-SEM）、能谱分析（EDX）、振动样品磁强计（VSM）和热重分析（TGA）技术进行了确认，有机产物的结构通过熔点、FT-IR 和 H NMR 分析进行了检验。
