Kesim Selin, Ozguven Salih, Oksuzoglu Kevser, Erdil Tanju Yusuf
From the Department of Nuclear Medicine, Marmara University Pendik Research and Training Hospital, Istanbul, Turkey.
Clin Nucl Med. 2023 Feb 1;48(2):e99-e100. doi: 10.1097/RLU.0000000000004382. Epub 2022 Sep 6.
Cowden syndrome is characterized by multiple hamartomatous and neoplastic lesions including Lhermitte-Duclos disease, which is the main criterion for the diagnosis. Herein, we presented a patient with suspected metastatic disease referred to PET/CT, which showed mildly hypermetabolic multinodular thyroid goiter, multiple hamartomatous pulmonary, and breast nodules. Also, intense hypermetabolism was noted on the cerebellar tumor lesion. Lhermitte-Duclos disease was diagnosed based on the characteristic MRI findings, and she was followed up with a diagnosis of Cowden syndrome. Our case indicates that Cowden syndrome should be included as a differential diagnosis of abnormal FDG uptake in the multiple systemic hamartomatous tumors.
