Biesman Brian, Verma Amit, Cheng Nuo, Duncan Ashlee
J Drugs Dermatol. 2023 Jan 1;22(1):74-81. doi: 10.36849/JDD.7191.
The infraorbital hollow is characterized by a sunken hollowing appearance of the junction between the lower eyelid and the cheek. Dermal fillers provide a suitable option to reduce the appearance of infraorbital hollowing. To objectively evaluate treatmentrelated improvements in clinical practice and research, a validated photonumeric scale is needed.
To present the scale development methods for the Merz Infraorbital Hollow Assessment Scale and establish its reliability and clinical relevance.
A 5-point photonumeric scale was developed to objectively assess the infraorbital hollowing among subjects of varying sex, age, and skin type. Intra- and inter-rater reliability was evaluated using live assessments conducted 2 weeks apart. The clinical relevance of a 1-point difference in scale-severity grade was evaluated through side by-side comparisons of photographs with either same grade or a one-grade difference.
The scale demonstrated excellent reliability when used by trained physicians and other healthcare practitioners. Intra-rater agreement between the 2 live-subject rating sessions was nearly perfect. Substantial inter-rater agreement between the raters from both live sessions was also demonstrated. The mean absolute difference (95% confidence interval) in scale ratings was 1.08 (1.02, 1.14) for "clinically different" pairs and was 0.34 (0.27, 0.41) for "clinically same" pairs, suggesting a 1-point difference is clinically relevant.
The Merz Infraorbital Hollow Assessment Scale is a validated, reliable, and clinically relevant photonumeric scale for rating infraorbital hollowing. The scale maintains its validity and reliability with reproducible results across a diverse group of males and females of various ages and Fitzpatrick Skin Types. J Drugs Dermatol. 2023;22(1):74-81.doi:10.36849/JDD.7191.
眶下凹陷的特征是下眼睑与脸颊交界处出现凹陷外观。真皮填充剂为减少眶下凹陷外观提供了一种合适的选择。为了在临床实践和研究中客观评估与治疗相关的改善情况，需要一个经过验证的数字评分量表。
介绍Merz眶下凹陷评估量表的量表开发方法，并确定其可靠性和临床相关性。
开发了一个5分数字评分量表，以客观评估不同性别、年龄和皮肤类型受试者的眶下凹陷情况。使用间隔2周进行的现场评估来评估评分者内和评分者间的可靠性。通过对相同等级或相差一个等级的照片进行并排比较，评估量表严重程度等级相差1分的临床相关性。
当由训练有素的医生和其他医疗从业者使用时，该量表显示出出色的可靠性。两次现场受试者评分之间的评分者内一致性几乎完美。两次现场评估的评分者之间也显示出高度的评分者间一致性。“临床不同”组的量表评分平均绝对差异（95%置信区间）为1.08（1.02，1.14），“临床相同”组为0.34（0.27，0.41），表明相差1分具有临床相关性。
Merz眶下凹陷评估量表是一种经过验证、可靠且具有临床相关性的数字评分量表，用于评估眶下凹陷。该量表在不同年龄和 Fitzpatrick皮肤类型的不同性别群体中保持其有效性和可靠性，结果具有可重复性。《药物皮肤病学杂志》。2023；22（1）：74 - 81。doi：10.36849/JDD.7̃191。
