Tao Heqing, Chang Hong, Li Nan, Zhu Shiwei, Duan Liping
From the Department of Gastroenterology.
Research Center of Clinical Epidemiology.
Pancreas. 2022 Sep 1;51(8):950-956. doi: 10.1097/MPA.0000000000002142.
The aim of the study is to clarify the clinical characteristics of patients with chronic pancreatitis (CP) who had no prior acute pancreatitis (AP) attack.
We retrospectively analyzed patients with CP who were admitted to our center between January 2012 and January 2020.
A total of 274 patients were divided into the following 3 groups: group A: CP without prior AP (n = 103 [37.6%]), group B: CP preceded by a single episode of AP (n = 39 [14.23%]), and group C: CP preceded by recurrent AP (n = 132 [48.18%]). At the diagnosis, patients in group A had a higher incidence of pancreatic duct stones (41.7% vs 25.8%, P = 0.012), higher proportion of idiopathic CP (68.9% vs 48.5%, P = 0.001), and higher mean pancreatic volume change rate (37.61% vs 10.48%, P = 0.007) compared with Group C. Patients in group A underwent the most episodes of extracorporeal shockwave lithotripsy therapy among the 3 groups (P < 0.001).
Approximately 37.6% of patients had no prior AP attack before CP diagnosis. Patients with CP without prior AP had higher incidence of pancreatic duct stones and pancreas volume shrank faster.
本研究旨在阐明既往无急性胰腺炎（AP）发作的慢性胰腺炎（CP）患者的临床特征。
我们回顾性分析了2012年1月至2020年1月期间入住本中心的CP患者。
共274例患者分为以下3组：A组：既往无AP的CP（n = 103 [37.6%]），B组：有单次AP发作史的CP（n = 39 [14.23%]），C组：有复发性AP发作史的CP（n = 132 [48.18%]）。诊断时，与C组相比，A组患者胰管结石发生率更高（41.7%对25.8%，P = 0.012），特发性CP比例更高（68.9%对48.5%，P = 0.001），平均胰腺体积变化率更高（37.61%对10.48%，P = 0.007）。A组患者接受体外冲击波碎石治疗的次数在3组中最多（P < 0.001）。
约37.6%的患者在CP诊断前无AP发作史。既往无AP的CP患者胰管结石发生率更高，胰腺体积缩小更快。
