Su Afang, Yuan Xiaojie, Zhu Guoling, Jiang Xiaozhong, Shu Rong, Yang Wenhao, Wu Shouling, Chen Shuohua, Wang Li, Cui Liufu
From the Department of Gastroenterology, Kailuan General Hospital, Tangshan.
Departments of Rheumatic Diseases.
Pancreas. 2022 Sep 1;51(8):966-971. doi: 10.1097/MPA.0000000000002137.
The aim of the study is explore the association between serum uric acid (UA) and acute pancreatitis (AP) risk in a Chinese population.
We included 124,316 participants who enrolled in the Kailuan cohort from 2006 to 2009. We fitted Cox models to estimate the correlation between UA and AP.
During an average follow-up of 11.97 years (standard deviation, 2.16 years), 396 AP developed. The incidence rates from quartile 1 to quartile 4 of AP were 20.76, 18.78, 30.58, and 36.79 per 100,000 person-years, respectively. Multivariate analysis showed a significantly increased risk in quartile 3 (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.05-1.91) and quartile 4 (HR, 1.61; 95% CI, 1.19-2.17) compared with quartile 1. The association may be modified by alcohol use (P for interaction = 0.017). The quartile 4 group with excessive alcohol consumption showed an enormously increased risk of AP (HR, 9.09; 95% CI, 1.18-70.21) than those without (HR, 1.46; 95% CI, 1.07-2.00).
Elevated serum UA is an independent risk factor for AP. Surveillance of serum UA, especially among heavy drinkers, may be helpful for AP prevention.
本研究旨在探讨中国人群中血清尿酸（UA）与急性胰腺炎（AP）风险之间的关联。
我们纳入了2006年至2009年参加开滦队列研究的124316名参与者。我们采用Cox模型来估计UA与AP之间的相关性。
在平均11.97年（标准差为2.16年）的随访期间，共发生396例AP。AP从第1四分位数到第4四分位数的发病率分别为每10万人年20.76、18.78、30.58和36.79例。多变量分析显示，与第1四分位数相比，第3四分位数（风险比[HR]，1.42；95%置信区间[CI]，1.05 - 1.91）和第4四分位数（HR，1.61；95% CI，1.19 - 2.17）的风险显著增加。这种关联可能会受到饮酒情况的影响（交互作用P值 = 0.017）。与不饮酒者相比，第4四分位数组中过量饮酒者发生AP的风险大幅增加（HR，9.09；95% CI，1.18 - 70.21），而不饮酒者的风险为（HR，1.46；95% CI，1.07 - 2.00）。
血清UA升高是AP的独立危险因素。监测血清UA，尤其是在重度饮酒者中，可能有助于预防AP。
