Doering F, Henschke E
Krankenhaus Saalkreis, Bereich Wettin.
Z Gesamte Inn Med. 1987 Jun 1;42(11):295-8.
In 74 patients with hypertension with an average age of 60 years on the basis of 8 measuring values the behaviour of blood pressure and frequency was controlled between 6 a.m. and 11 p.m. during the administration of the calcium antagonist nifedipine. The average blood pressure decreased from 198/106 to 178/89 mm Hg during the nifedipine treatment. The scope of the decrease of blood pressure was significantly higher in the patients older than 60 years than in the younger patients. At the same time the blood pressure values very much decreased in patients with the higher values. The heart rate increased only in patients of older age under the administration of nifedipine. The circadian rhythm of the blood pressure, in particular the matutinal increase of blood pressure, could not be influenced.
在74名平均年龄为60岁的高血压患者中，基于8个测量值，在服用钙拮抗剂硝苯地平期间，于上午6点至晚上11点对血压行为和频率进行了监测。硝苯地平治疗期间，平均血压从198/106毫米汞柱降至178/89毫米汞柱。60岁以上患者的血压下降幅度明显高于年轻患者。同时，血压值较高的患者血压下降幅度很大。服用硝苯地平期间，仅老年患者的心率增加。血压的昼夜节律，尤其是血压的晨峰，未受影响。
