Stoz F, Schultz R, Kohne E, Schuhmann R A
Sektion Gynäkologische Zytologie und Histologie, Universitäts-Frauenklinik Ulm.
Z Geburtshilfe Perinatol. 1987 May-Jun;191(3):81-4.
According to the criteria formulated by the WHO a hemoglobin concentration of 11 g/% represents an anaemia requiring treatment. 28 placentas of patients with hemoglobin concentrations of 7.2 to 10.9 g/% were examined morphometrically to detect possible disturbances of placental development. The patients had all delivered between the 37th and 41st week. Weight, hematocrit and HbA content of the newborn were correlated with the maternal hemoglobin content. There was no influence of maternal hemoglobin concentration on weight and size of the placenta, degree of vascularization and epithelial plates of the terminal villi. In patients with severe anaemia villous areas were smaller and villous vascular areas appeared larger than usual. The ratio of weight of the newborn to weight of the placenta was more commonly decreased in patients with anaemia. In some cases of severe anaemia fetal HbA values were elevated. All newborns with a hematocrit of 50 or more were delivered of mothers with haemoglobin concentrations of 9.5 g/% or less. The weight of all newborns in this study were above the 10th percentile. 7 of 9 newborns with a weight of 3,200 g or less were delivered of patients with a hemoglobin concentration of 9.5 g/% or less. These results indicate that placenta and fetal organ systems are able to compensate for the maternal anaemia without any major complications.
根据世界卫生组织制定的标准，血红蛋白浓度为11克/％代表需要治疗的贫血。对28例血红蛋白浓度为7.2至10.9克/％的患者的胎盘进行形态计量学检查，以检测胎盘发育可能存在的紊乱。这些患者均在第37至41周之间分娩。新生儿的体重、血细胞比容和HbA含量与母亲的血红蛋白含量相关。母亲血红蛋白浓度对胎盘的重量和大小、终末绒毛的血管化程度和上皮板没有影响。重度贫血患者的绒毛面积较小，绒毛血管面积似乎比正常情况大。贫血患者中，新生儿体重与胎盘重量的比值更常降低。在某些重度贫血病例中，胎儿HbA值升高。所有血细胞比容为50或更高的新生儿，其母亲的血红蛋白浓度均为9.5克/％或更低。本研究中所有新生儿的体重均高于第10百分位数。9例体重为3200克或更低的新生儿中，有7例是由血红蛋白浓度为9.5克/％或更低的患者分娩的。这些结果表明，胎盘和胎儿器官系统能够补偿母亲的贫血，而不会出现任何重大并发症。
